TY - JOUR
T1 - The structure of schizotypy
T2 - Relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study
AU - Nuechterlein, Keith H.
AU - Asarnow, Robert F.
AU - Subotnik, Kenneth L.
AU - Fogelson, David L.
AU - Payne, Diana L.
AU - Kendler, Kenneth S.
AU - Neale, Michael C.
AU - Jacobson, Kristen C.
AU - Mintz, Jim
N1 - Funding Information:
This research was supported in part by NIMH grants MH49716, MH45112, MH37705, MH30792, MH14584, and MH30911 and by a grant from the John D. and Catherine T. MacArthur Foundation Research Network on Risk and Protective Factors in the Major Mental Disorders. We acknowledge the very helpful statistical services of Sun Hwang, M.S., M.P.H. The authors also wish to thank Dr. Bengt Muthén for the statistical consultation and the staff and participants of the UCLA Family Study for their essential contributions to this effort. This article benefitted from the insightful comments of Drs. Bruce Wexler and Meinte Vollema, following an oral presentation of its contents at the NATO Advanced Research Workshop.
PY - 2002/3/1
Y1 - 2002/3/1
N2 - Schizotypal personality features and certain neurocognitive deficits have been shown to aggregate in the relatives of schizophrenic patients, supporting the view that both are likely to reflect genetic contributions to liability to schizophrenia. Within the relatives of schizophrenic patients, however, the interrelationships between these potential indicators of liability to schizophrenia are not well known. Using data from the UCLA Family Study, we examine the interrelationships between personality disorder symptoms and neurocognitive functioning in nonpsychotic first-degree relatives of schizophrenic patients. Factor analyses indicate that several dimensions of schizotypy can be identified. A neurocognitive dysfunction dimension includes loadings from measures of sequential visual conceptual tracking, rapid perceptual encoding and search, and focused, sustained attention as well as the rating of odd and eccentric behavior from schizotypal personality disorder. Other aspects of schizotypal personality disorder form separate positive schizotypy and negative schizotypy dimensions. These analyses support the view that schizotypy is multidimensional in relatives of schizophrenic patients and indicate that neurocognitive deficits in perception and attention are associated with particular schizotypal personality features.
AB - Schizotypal personality features and certain neurocognitive deficits have been shown to aggregate in the relatives of schizophrenic patients, supporting the view that both are likely to reflect genetic contributions to liability to schizophrenia. Within the relatives of schizophrenic patients, however, the interrelationships between these potential indicators of liability to schizophrenia are not well known. Using data from the UCLA Family Study, we examine the interrelationships between personality disorder symptoms and neurocognitive functioning in nonpsychotic first-degree relatives of schizophrenic patients. Factor analyses indicate that several dimensions of schizotypy can be identified. A neurocognitive dysfunction dimension includes loadings from measures of sequential visual conceptual tracking, rapid perceptual encoding and search, and focused, sustained attention as well as the rating of odd and eccentric behavior from schizotypal personality disorder. Other aspects of schizotypal personality disorder form separate positive schizotypy and negative schizotypy dimensions. These analyses support the view that schizotypy is multidimensional in relatives of schizophrenic patients and indicate that neurocognitive deficits in perception and attention are associated with particular schizotypal personality features.
KW - Neurocognitive deficits
KW - Schizophrenia
KW - Schizotypal personality
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U2 - 10.1016/S0920-9964(01)00359-0
DO - 10.1016/S0920-9964(01)00359-0
M3 - Article
C2 - 11853986
AN - SCOPUS:0036498842
VL - 54
SP - 121
EP - 130
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-2
ER -