The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Anokha S. Ratnayake, Wesley Y. Yoshida, Susan L. Mooberry, Thomas Hemscheidt

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

(matrix presented) A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.

Original languageEnglish (US)
Pages (from-to)3479-3481
Number of pages3
JournalOrganic Letters
Volume3
Issue number22
DOIs
StatePublished - Nov 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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