The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Anokha S. Ratnayake; Wesley Y. Yoshida; Susan L. Mooberry; Thomas Hemscheidt

doi:10.1021/ol016515s

The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Anokha S. Ratnayake, Wesley Y. Yoshida, Susan L. Mooberry, Thomas Hemscheidt

Pharmacology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

(matrix presented) A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.

Original language	English (US)
Pages (from-to)	3479-3481
Number of pages	3
Journal	Organic Letters
Volume	3
Issue number	22
DOIs	https://doi.org/10.1021/ol016515s
State	Published - Nov 1 2001

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol016515s

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abstract = "(matrix presented) A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.",

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AU - Hemscheidt, Thomas

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AB - (matrix presented) A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.

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The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Abstract

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