The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Anokha S. Ratnayake; Wesley Y. Yoshida; Susan L. Mooberry; Thomas Hemscheidt

doi:10.1021/ol016515s

The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Anokha S. Ratnayake, Wesley Y. Yoshida, Susan L. Mooberry, Thomas Hemscheidt

Pharmacology

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59 Scopus citations

Abstract

(matrix presented) A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.

Original language	English (US)
Pages (from-to)	3479-3481
Number of pages	3
Journal	Organic Letters
Volume	3
Issue number	22
DOIs	https://doi.org/10.1021/ol016515s
Publication status	Published - Nov 1 2001

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Ratnayake, A. S., Yoshida, W. Y., Mooberry, S. L., & Hemscheidt, T. (2001). The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus. Organic Letters, 3(22), 3479-3481. https://doi.org/10.1021/ol016515s

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Access to Document

10.1021/ol016515s