The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury

Eric M. Sikorski, Thomas Hock, Nathalie S Hill-kapturczak, Anupam Agarwal

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

Heme oxygenases (HOs) catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, the latter of which is subsequently converted to bilirubin by biliverdin reductase. Recent attention has focused on the biological effects of product(s) of this enzymatic reaction, which have important antioxidant, anti-inflammatory, and cytoprotective functions. Two major isoforms of the HO enzyme have been described: an inducible isoform, HO-1, and a constitutively expressed isoform, HO-2. A third isoform, HO-3, closely related to HO-2, has also been described. Several stimuli implicated in the pathogenesis of renal injury, such as heme, nitric oxide, growth factors, angiotensin II, cytokines, and nephrotoxins, induce HO-1. Induction of HO-1 occurs as an adaptive and beneficial response to these stimuli, as demonstrated by studies in renal and non-renal disease states. This review will focus on the molecular regulation of the HO-1 gene in renal injury and will highlight the interspecies differences, predominantly between the rodent and human HO-1 genes.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume286
Issue number3 55-3
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Heme Oxygenase-1
Heme Oxygenase (Decyclizing)
Kidney
Protein Isoforms
Wounds and Injuries
biliverdin reductase
Genes
Heme
Biliverdine
Carbon Monoxide
Bilirubin
Angiotensin II
Rodentia
Intercellular Signaling Peptides and Proteins
Nitric Oxide
Anti-Inflammatory Agents
Iron
Antioxidants
Cytokines
Enzymes

Keywords

  • Gene transcription
  • Heme proteins
  • Oxidant stress

ASJC Scopus subject areas

  • Physiology

Cite this

Sikorski, E. M., Hock, T., Hill-kapturczak, N. S., & Agarwal, A. (2004). The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury. American Journal of Physiology - Renal Physiology, 286(3 55-3).

The story so far : Molecular regulation of the heme oxygenase-1 gene in renal injury. / Sikorski, Eric M.; Hock, Thomas; Hill-kapturczak, Nathalie S; Agarwal, Anupam.

In: American Journal of Physiology - Renal Physiology, Vol. 286, No. 3 55-3, 03.2004.

Research output: Contribution to journalArticle

Sikorski, EM, Hock, T, Hill-kapturczak, NS & Agarwal, A 2004, 'The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury', American Journal of Physiology - Renal Physiology, vol. 286, no. 3 55-3.
Sikorski, Eric M. ; Hock, Thomas ; Hill-kapturczak, Nathalie S ; Agarwal, Anupam. / The story so far : Molecular regulation of the heme oxygenase-1 gene in renal injury. In: American Journal of Physiology - Renal Physiology. 2004 ; Vol. 286, No. 3 55-3.
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