The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition

Victor Kim, Huaqing Zhao, Elizabeth Regan, Mei Lan K. Han, Barry J. Make, James D. Crapo, Paul W. Jones, Jeffrey L. Curtis, Edwin K. Silverman, Gerard J. Criner, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Robert Busch, Peter J. Castaldi, Michael Cho, Dawn L. DeMeo, Adel R. Boueiz, Marilyn G. Foreman, Eitan Halper-StrombergNadia N. Hansel, Megan E. Hardin, Lystra P. Hayden, Craig P. Hersh, Jacqueline Hetmanski, Brian D. Hobbs, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry Lynn McDonald, Margaret M. Parker, Dandi Qiao, Stephanie Santorico, Emily S. Wan, Sungho Won, Jean Paul Charbonnier, Harvey O. Coxson, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, John D. Newell, James C. Ross, Raul San Jose Estepar, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Bram van Ginneken, Eva van Rikxoort, George Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Camille Moore, Matt Strand, John Hughes, Gregory Kinney, Katherine Pratte, Kendra A. Young, Carlos H. Martinez, Perry G. Pernicano, Nicola Hanania, Philip Alapat, Mustafa Atik, Venkata Bandi, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Arun Nachiappan, Amit Parulekar, Craig Hersh, R. Graham Barr, John Austin, Belinda D'Souza, Gregory D.N. Pearson, Anna Rozenshtein, Byron Thomashow, Neil MacIntyre, H. Page McAdams, Lacey Washington, Charlene McEvoy, Joseph Tashjian, Robert Wise, Robert Brown, Karen Horton, Allison Lambert, Nirupama Putcha, Richard Casaburi, Alessandra Adami, Matthew Budoff, Hans Fischer, Janos Porszasz, Harry Rossiter, William Stringer, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Eugene Berkowitz, Eric L. Flenaugh, Gloria Westney, Russell Bowler, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert D'Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, A. James Mamary, Nathaniel Marchetti, Aditi Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Maria Elena Vega-Sanchez, Mark Dransfield, William Bailey, Surya Bhatt, Anand Iyer, Hrudaya Nath, Gabriela Oates, Sushil Sonavane, J. Michael Wells, Joe Ramsdell, Paul Friedman, Xavier Soler, Andrew Yen, Alejandro P. Comellas, John Newell, Brad Thompson, Ella Kazerooni, Joanne Billings, Abbie Begnaud, Tadashi Allen, Frank Sciurba, Jessica Bon, Divay Chandra, Carl Fuhrman, Joel Weissfeld, Antonio Anzueto, Sandra Adams, Diego Maselli-Caceres, Mario E. Ruiz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George's Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods: We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates. Results: There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not. Conclusions: The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.

Original languageEnglish (US)
JournalChest
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Surveys and Questionnaires

Keywords

  • chronic bronchitis
  • COPD
  • cough
  • exacerbations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition. / Kim, Victor; Zhao, Huaqing; Regan, Elizabeth; Han, Mei Lan K.; Make, Barry J.; Crapo, James D.; Jones, Paul W.; Curtis, Jeffrey L.; Silverman, Edwin K.; Criner, Gerard J.; Regan, Elizabeth A.; Beaty, Terri; Begum, Ferdouse; Busch, Robert; Castaldi, Peter J.; Cho, Michael; DeMeo, Dawn L.; Boueiz, Adel R.; Foreman, Marilyn G.; Halper-Stromberg, Eitan; Hansel, Nadia N.; Hardin, Megan E.; Hayden, Lystra P.; Hersh, Craig P.; Hetmanski, Jacqueline; Hobbs, Brian D.; Hokanson, John E.; Laird, Nan; Lange, Christoph; Lutz, Sharon M.; McDonald, Merry Lynn; Parker, Margaret M.; Qiao, Dandi; Santorico, Stephanie; Wan, Emily S.; Won, Sungho; Charbonnier, Jean Paul; Coxson, Harvey O.; Hoffman, Eric A.; Humphries, Stephen; Jacobson, Francine L.; Judy, Philip F.; Kazerooni, Ella A.; Kluiber, Alex; Lynch, David A.; Newell, John D.; Ross, James C.; San Jose Estepar, Raul; Sieren, Jered; Stoel, Berend C.; Tschirren, Juerg; Van Beek, Edwin; van Ginneken, Bram; van Rikxoort, Eva; Washko, George; Wilson, Carla G.; Jensen, Robert; Everett, Douglas; Crooks, Jim; Moore, Camille; Strand, Matt; Hughes, John; Kinney, Gregory; Pratte, Katherine; Young, Kendra A.; Martinez, Carlos H.; Pernicano, Perry G.; Hanania, Nicola; Alapat, Philip; Atik, Mustafa; Bandi, Venkata; Boriek, Aladin; Guntupalli, Kalpatha; Guy, Elizabeth; Nachiappan, Arun; Parulekar, Amit; Hersh, Craig; Barr, R. Graham; Austin, John; D'Souza, Belinda; Pearson, Gregory D.N.; Rozenshtein, Anna; Thomashow, Byron; MacIntyre, Neil; McAdams, H. Page; Washington, Lacey; McEvoy, Charlene; Tashjian, Joseph; Wise, Robert; Brown, Robert; Horton, Karen; Lambert, Allison; Putcha, Nirupama; Casaburi, Richard; Adami, Alessandra; Budoff, Matthew; Fischer, Hans; Porszasz, Janos; Rossiter, Harry; Stringer, William; Sharafkhaneh, Amir; Lan, Charlie; Wendt, Christine; Bell, Brian; Berkowitz, Eugene; Flenaugh, Eric L.; Westney, Gloria; Bowler, Russell; Rosiello, Richard; Pace, David; Criner, Gerard; Ciccolella, David; Cordova, Francis; Dass, Chandra; D'Alonzo, Gilbert; Desai, Parag; Jacobs, Michael; Kelsen, Steven; Mamary, A. James; Marchetti, Nathaniel; Satti, Aditi; Shenoy, Kartik; Steiner, Robert M.; Swift, Alex; Swift, Irene; Vega-Sanchez, Maria Elena; Dransfield, Mark; Bailey, William; Bhatt, Surya; Iyer, Anand; Nath, Hrudaya; Oates, Gabriela; Sonavane, Sushil; Wells, J. Michael; Ramsdell, Joe; Friedman, Paul; Soler, Xavier; Yen, Andrew; Comellas, Alejandro P.; Newell, John; Thompson, Brad; Kazerooni, Ella; Billings, Joanne; Begnaud, Abbie; Allen, Tadashi; Sciurba, Frank; Bon, Jessica; Chandra, Divay; Fuhrman, Carl; Weissfeld, Joel; Anzueto, Antonio; Adams, Sandra; Maselli-Caceres, Diego; Ruiz, Mario E.

In: Chest, 01.01.2019.

Research output: Contribution to journalArticle

Kim, V, Zhao, H, Regan, E, Han, MLK, Make, BJ, Crapo, JD, Jones, PW, Curtis, JL, Silverman, EK, Criner, GJ, Regan, EA, Beaty, T, Begum, F, Busch, R, Castaldi, PJ, Cho, M, DeMeo, DL, Boueiz, AR, Foreman, MG, Halper-Stromberg, E, Hansel, NN, Hardin, ME, Hayden, LP, Hersh, CP, Hetmanski, J, Hobbs, BD, Hokanson, JE, Laird, N, Lange, C, Lutz, SM, McDonald, ML, Parker, MM, Qiao, D, Santorico, S, Wan, ES, Won, S, Charbonnier, JP, Coxson, HO, Hoffman, EA, Humphries, S, Jacobson, FL, Judy, PF, Kazerooni, EA, Kluiber, A, Lynch, DA, Newell, JD, Ross, JC, San Jose Estepar, R, Sieren, J, Stoel, BC, Tschirren, J, Van Beek, E, van Ginneken, B, van Rikxoort, E, Washko, G, Wilson, CG, Jensen, R, Everett, D, Crooks, J, Moore, C, Strand, M, Hughes, J, Kinney, G, Pratte, K, Young, KA, Martinez, CH, Pernicano, PG, Hanania, N, Alapat, P, Atik, M, Bandi, V, Boriek, A, Guntupalli, K, Guy, E, Nachiappan, A, Parulekar, A, Hersh, C, Barr, RG, Austin, J, D'Souza, B, Pearson, GDN, Rozenshtein, A, Thomashow, B, MacIntyre, N, McAdams, HP, Washington, L, McEvoy, C, Tashjian, J, Wise, R, Brown, R, Horton, K, Lambert, A, Putcha, N, Casaburi, R, Adami, A, Budoff, M, Fischer, H, Porszasz, J, Rossiter, H, Stringer, W, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Berkowitz, E, Flenaugh, EL, Westney, G, Bowler, R, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, G, Desai, P, Jacobs, M, Kelsen, S, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, ME, Dransfield, M, Bailey, W, Bhatt, S, Iyer, A, Nath, H, Oates, G, Sonavane, S, Wells, JM, Ramsdell, J, Friedman, P, Soler, X, Yen, A, Comellas, AP, Newell, J, Thompson, B, Kazerooni, E, Billings, J, Begnaud, A, Allen, T, Sciurba, F, Bon, J, Chandra, D, Fuhrman, C, Weissfeld, J, Anzueto, A, Adams, S, Maselli-Caceres, D & Ruiz, ME 2019, 'The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition', Chest. https://doi.org/10.1016/j.chest.2019.03.041
Kim, Victor ; Zhao, Huaqing ; Regan, Elizabeth ; Han, Mei Lan K. ; Make, Barry J. ; Crapo, James D. ; Jones, Paul W. ; Curtis, Jeffrey L. ; Silverman, Edwin K. ; Criner, Gerard J. ; Regan, Elizabeth A. ; Beaty, Terri ; Begum, Ferdouse ; Busch, Robert ; Castaldi, Peter J. ; Cho, Michael ; DeMeo, Dawn L. ; Boueiz, Adel R. ; Foreman, Marilyn G. ; Halper-Stromberg, Eitan ; Hansel, Nadia N. ; Hardin, Megan E. ; Hayden, Lystra P. ; Hersh, Craig P. ; Hetmanski, Jacqueline ; Hobbs, Brian D. ; Hokanson, John E. ; Laird, Nan ; Lange, Christoph ; Lutz, Sharon M. ; McDonald, Merry Lynn ; Parker, Margaret M. ; Qiao, Dandi ; Santorico, Stephanie ; Wan, Emily S. ; Won, Sungho ; Charbonnier, Jean Paul ; Coxson, Harvey O. ; Hoffman, Eric A. ; Humphries, Stephen ; Jacobson, Francine L. ; Judy, Philip F. ; Kazerooni, Ella A. ; Kluiber, Alex ; Lynch, David A. ; Newell, John D. ; Ross, James C. ; San Jose Estepar, Raul ; Sieren, Jered ; Stoel, Berend C. ; Tschirren, Juerg ; Van Beek, Edwin ; van Ginneken, Bram ; van Rikxoort, Eva ; Washko, George ; Wilson, Carla G. ; Jensen, Robert ; Everett, Douglas ; Crooks, Jim ; Moore, Camille ; Strand, Matt ; Hughes, John ; Kinney, Gregory ; Pratte, Katherine ; Young, Kendra A. ; Martinez, Carlos H. ; Pernicano, Perry G. ; Hanania, Nicola ; Alapat, Philip ; Atik, Mustafa ; Bandi, Venkata ; Boriek, Aladin ; Guntupalli, Kalpatha ; Guy, Elizabeth ; Nachiappan, Arun ; Parulekar, Amit ; Hersh, Craig ; Barr, R. Graham ; Austin, John ; D'Souza, Belinda ; Pearson, Gregory D.N. ; Rozenshtein, Anna ; Thomashow, Byron ; MacIntyre, Neil ; McAdams, H. Page ; Washington, Lacey ; McEvoy, Charlene ; Tashjian, Joseph ; Wise, Robert ; Brown, Robert ; Horton, Karen ; Lambert, Allison ; Putcha, Nirupama ; Casaburi, Richard ; Adami, Alessandra ; Budoff, Matthew ; Fischer, Hans ; Porszasz, Janos ; Rossiter, Harry ; Stringer, William ; Sharafkhaneh, Amir ; Lan, Charlie ; Wendt, Christine ; Bell, Brian ; Berkowitz, Eugene ; Flenaugh, Eric L. ; Westney, Gloria ; Bowler, Russell ; Rosiello, Richard ; Pace, David ; Criner, Gerard ; Ciccolella, David ; Cordova, Francis ; Dass, Chandra ; D'Alonzo, Gilbert ; Desai, Parag ; Jacobs, Michael ; Kelsen, Steven ; Mamary, A. James ; Marchetti, Nathaniel ; Satti, Aditi ; Shenoy, Kartik ; Steiner, Robert M. ; Swift, Alex ; Swift, Irene ; Vega-Sanchez, Maria Elena ; Dransfield, Mark ; Bailey, William ; Bhatt, Surya ; Iyer, Anand ; Nath, Hrudaya ; Oates, Gabriela ; Sonavane, Sushil ; Wells, J. Michael ; Ramsdell, Joe ; Friedman, Paul ; Soler, Xavier ; Yen, Andrew ; Comellas, Alejandro P. ; Newell, John ; Thompson, Brad ; Kazerooni, Ella ; Billings, Joanne ; Begnaud, Abbie ; Allen, Tadashi ; Sciurba, Frank ; Bon, Jessica ; Chandra, Divay ; Fuhrman, Carl ; Weissfeld, Joel ; Anzueto, Antonio ; Adams, Sandra ; Maselli-Caceres, Diego ; Ruiz, Mario E. / The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition. In: Chest. 2019.
@article{47936dbf52154ebd9f2e86217124412b,
title = "The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition",
abstract = "Background: Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George's Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods: We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates. Results: There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not. Conclusions: The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.",
keywords = "chronic bronchitis, COPD, cough, exacerbations",
author = "Victor Kim and Huaqing Zhao and Elizabeth Regan and Han, {Mei Lan K.} and Make, {Barry J.} and Crapo, {James D.} and Jones, {Paul W.} and Curtis, {Jeffrey L.} and Silverman, {Edwin K.} and Criner, {Gerard J.} and Regan, {Elizabeth A.} and Terri Beaty and Ferdouse Begum and Robert Busch and Castaldi, {Peter J.} and Michael Cho and DeMeo, {Dawn L.} and Boueiz, {Adel R.} and Foreman, {Marilyn G.} and Eitan Halper-Stromberg and Hansel, {Nadia N.} and Hardin, {Megan E.} and Hayden, {Lystra P.} and Hersh, {Craig P.} and Jacqueline Hetmanski and Hobbs, {Brian D.} and Hokanson, {John E.} and Nan Laird and Christoph Lange and Lutz, {Sharon M.} and McDonald, {Merry Lynn} and Parker, {Margaret M.} and Dandi Qiao and Stephanie Santorico and Wan, {Emily S.} and Sungho Won and Charbonnier, {Jean Paul} and Coxson, {Harvey O.} and Hoffman, {Eric A.} and Stephen Humphries and Jacobson, {Francine L.} and Judy, {Philip F.} and Kazerooni, {Ella A.} and Alex Kluiber and Lynch, {David A.} and Newell, {John D.} and Ross, {James C.} and {San Jose Estepar}, Raul and Jered Sieren and Stoel, {Berend C.} and Juerg Tschirren and {Van Beek}, Edwin and {van Ginneken}, Bram and {van Rikxoort}, Eva and George Washko and Wilson, {Carla G.} and Robert Jensen and Douglas Everett and Jim Crooks and Camille Moore and Matt Strand and John Hughes and Gregory Kinney and Katherine Pratte and Young, {Kendra A.} and Martinez, {Carlos H.} and Pernicano, {Perry G.} and Nicola Hanania and Philip Alapat and Mustafa Atik and Venkata Bandi and Aladin Boriek and Kalpatha Guntupalli and Elizabeth Guy and Arun Nachiappan and Amit Parulekar and Craig Hersh and Barr, {R. Graham} and John Austin and Belinda D'Souza and Pearson, {Gregory D.N.} and Anna Rozenshtein and Byron Thomashow and Neil MacIntyre and McAdams, {H. Page} and Lacey Washington and Charlene McEvoy and Joseph Tashjian and Robert Wise and Robert Brown and Karen Horton and Allison Lambert and Nirupama Putcha and Richard Casaburi and Alessandra Adami and Matthew Budoff and Hans Fischer and Janos Porszasz and Harry Rossiter and William Stringer and Amir Sharafkhaneh and Charlie Lan and Christine Wendt and Brian Bell and Eugene Berkowitz and Flenaugh, {Eric L.} and Gloria Westney and Russell Bowler and Richard Rosiello and David Pace and Gerard Criner and David Ciccolella and Francis Cordova and Chandra Dass and Gilbert D'Alonzo and Parag Desai and Michael Jacobs and Steven Kelsen and Mamary, {A. James} and Nathaniel Marchetti and Aditi Satti and Kartik Shenoy and Steiner, {Robert M.} and Alex Swift and Irene Swift and Vega-Sanchez, {Maria Elena} and Mark Dransfield and William Bailey and Surya Bhatt and Anand Iyer and Hrudaya Nath and Gabriela Oates and Sushil Sonavane and Wells, {J. Michael} and Joe Ramsdell and Paul Friedman and Xavier Soler and Andrew Yen and Comellas, {Alejandro P.} and John Newell and Brad Thompson and Ella Kazerooni and Joanne Billings and Abbie Begnaud and Tadashi Allen and Frank Sciurba and Jessica Bon and Divay Chandra and Carl Fuhrman and Joel Weissfeld and Antonio Anzueto and Sandra Adams and Diego Maselli-Caceres and Ruiz, {Mario E.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.chest.2019.03.041",
language = "English (US)",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",

}

TY - JOUR

T1 - The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition

AU - Kim, Victor

AU - Zhao, Huaqing

AU - Regan, Elizabeth

AU - Han, Mei Lan K.

AU - Make, Barry J.

AU - Crapo, James D.

AU - Jones, Paul W.

AU - Curtis, Jeffrey L.

AU - Silverman, Edwin K.

AU - Criner, Gerard J.

AU - Regan, Elizabeth A.

AU - Beaty, Terri

AU - Begum, Ferdouse

AU - Busch, Robert

AU - Castaldi, Peter J.

AU - Cho, Michael

AU - DeMeo, Dawn L.

AU - Boueiz, Adel R.

AU - Foreman, Marilyn G.

AU - Halper-Stromberg, Eitan

AU - Hansel, Nadia N.

AU - Hardin, Megan E.

AU - Hayden, Lystra P.

AU - Hersh, Craig P.

AU - Hetmanski, Jacqueline

AU - Hobbs, Brian D.

AU - Hokanson, John E.

AU - Laird, Nan

AU - Lange, Christoph

AU - Lutz, Sharon M.

AU - McDonald, Merry Lynn

AU - Parker, Margaret M.

AU - Qiao, Dandi

AU - Santorico, Stephanie

AU - Wan, Emily S.

AU - Won, Sungho

AU - Charbonnier, Jean Paul

AU - Coxson, Harvey O.

AU - Hoffman, Eric A.

AU - Humphries, Stephen

AU - Jacobson, Francine L.

AU - Judy, Philip F.

AU - Kazerooni, Ella A.

AU - Kluiber, Alex

AU - Lynch, David A.

AU - Newell, John D.

AU - Ross, James C.

AU - San Jose Estepar, Raul

AU - Sieren, Jered

AU - Stoel, Berend C.

AU - Tschirren, Juerg

AU - Van Beek, Edwin

AU - van Ginneken, Bram

AU - van Rikxoort, Eva

AU - Washko, George

AU - Wilson, Carla G.

AU - Jensen, Robert

AU - Everett, Douglas

AU - Crooks, Jim

AU - Moore, Camille

AU - Strand, Matt

AU - Hughes, John

AU - Kinney, Gregory

AU - Pratte, Katherine

AU - Young, Kendra A.

AU - Martinez, Carlos H.

AU - Pernicano, Perry G.

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Atik, Mustafa

AU - Bandi, Venkata

AU - Boriek, Aladin

AU - Guntupalli, Kalpatha

AU - Guy, Elizabeth

AU - Nachiappan, Arun

AU - Parulekar, Amit

AU - Hersh, Craig

AU - Barr, R. Graham

AU - Austin, John

AU - D'Souza, Belinda

AU - Pearson, Gregory D.N.

AU - Rozenshtein, Anna

AU - Thomashow, Byron

AU - MacIntyre, Neil

AU - McAdams, H. Page

AU - Washington, Lacey

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert

AU - Brown, Robert

AU - Horton, Karen

AU - Lambert, Allison

AU - Putcha, Nirupama

AU - Casaburi, Richard

AU - Adami, Alessandra

AU - Budoff, Matthew

AU - Fischer, Hans

AU - Porszasz, Janos

AU - Rossiter, Harry

AU - Stringer, William

AU - Sharafkhaneh, Amir

AU - Lan, Charlie

AU - Wendt, Christine

AU - Bell, Brian

AU - Berkowitz, Eugene

AU - Flenaugh, Eric L.

AU - Westney, Gloria

AU - Bowler, Russell

AU - Rosiello, Richard

AU - Pace, David

AU - Criner, Gerard

AU - Ciccolella, David

AU - Cordova, Francis

AU - Dass, Chandra

AU - D'Alonzo, Gilbert

AU - Desai, Parag

AU - Jacobs, Michael

AU - Kelsen, Steven

AU - Mamary, A. James

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - Shenoy, Kartik

AU - Steiner, Robert M.

AU - Swift, Alex

AU - Swift, Irene

AU - Vega-Sanchez, Maria Elena

AU - Dransfield, Mark

AU - Bailey, William

AU - Bhatt, Surya

AU - Iyer, Anand

AU - Nath, Hrudaya

AU - Oates, Gabriela

AU - Sonavane, Sushil

AU - Wells, J. Michael

AU - Ramsdell, Joe

AU - Friedman, Paul

AU - Soler, Xavier

AU - Yen, Andrew

AU - Comellas, Alejandro P.

AU - Newell, John

AU - Thompson, Brad

AU - Kazerooni, Ella

AU - Billings, Joanne

AU - Begnaud, Abbie

AU - Allen, Tadashi

AU - Sciurba, Frank

AU - Bon, Jessica

AU - Chandra, Divay

AU - Fuhrman, Carl

AU - Weissfeld, Joel

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Maselli-Caceres, Diego

AU - Ruiz, Mario E.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George's Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods: We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates. Results: There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not. Conclusions: The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.

AB - Background: Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George's Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods: We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates. Results: There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not. Conclusions: The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.

KW - chronic bronchitis

KW - COPD

KW - cough

KW - exacerbations

UR - http://www.scopus.com/inward/record.url?scp=85067359671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067359671&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2019.03.041

DO - 10.1016/j.chest.2019.03.041

M3 - Article

C2 - 31047955

AN - SCOPUS:85067359671

JO - Chest

JF - Chest

SN - 0012-3692

ER -