The specificity of antibodies elicited by poly(Dg) poly(dc)

Eileen M. Lafer; B. David Stollar

doi:10.1080/07391102.1984.10507586

The specificity of antibodies elicited by poly(Dg) poly(dc)

Eileen M. Lafer, B. David Stollar

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Antibodies have been raised to the synthetic DNA polymer poly(dG) poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum.

Original language	English (US)
Pages (from-to)	487-494
Number of pages	8
Journal	Journal of Biomolecular Structure and Dynamics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1080/07391102.1984.10507586
State	Published - Dec 1984
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1080/07391102.1984.10507586

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abstract = "Antibodies have been raised to the synthetic DNA polymer poly(dG) poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum.",

author = "Lafer, {Eileen M.} and {David Stollar}, B.",

note = "Funding Information: This work was supported by grant GM-32375 from the National Institutes of Health. We thank Drs. Andrew H.-J. Wang and Michael McMillan for helpful discussions.",

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AU - Lafer, Eileen M.

AU - David Stollar, B.

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PY - 1984/12

Y1 - 1984/12

N2 - Antibodies have been raised to the synthetic DNA polymer poly(dG) poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum.

AB - Antibodies have been raised to the synthetic DNA polymer poly(dG) poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum.

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The specificity of antibodies elicited by poly(Dg) poly(dc)

Abstract

ASJC Scopus subject areas

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