The spatial distribution of Schistosoma mansoni infection before and after chemotherapy in the Jequitinhonha Valley in Brazil

Andrea Gazzinelli, Allen Hightower, Philip T. LoVerde, João Paulo Amaral Haddad, Wesley Rodrigues Pereira, Jeffrey Bethony, Rodrigo Correa-Oliveira, Helmut Kloos

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Schistosomiasis prevalence and egg counts remained low one year after chemotherapy in most households in a hyperendemic rural area in northern Minas Gerais but several distinct spatial patterns could be observed in relation to IgE levels and to a lesser extent to exposure risk (TBM) and type of water supply. An inverse relationship between pre-treatment household prevalence and egg counts on the one hand and post-treatment IgE levels on the other were noted in two of the five communities. Low exposure risk was associated with the low pre-treatment infection rates in the central village but did not contribute to the decline of infection rates after chemotherapy in the study area, as indicated by the significant increase in water contact during the posttreatment period (p < 0.0001). Distance between households and the streams and socioeconomic factors were also unimportant in predicting the spatial distribution of infection. These results are consistent with the production and antiparasitic effect of high levels of IgE in Schistosoma mansoni infection.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalMemorias do Instituto Oswaldo Cruz
Volume101
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 2006

Keywords

  • Brazil
  • Chemotherapy
  • Exposure risk
  • IgE antibodies
  • Nursing
  • Schistosomiasis
  • Spatial clustering

ASJC Scopus subject areas

  • Microbiology (medical)

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