The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Background: The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods: 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results: NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions: These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM.

Original languageEnglish (US)
Pages (from-to)280-286
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Issue number4
StatePublished - May 2010


  • OGTT
  • Prediction of diabetes
  • Shape of glucose tolerance curve

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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