The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders

J. Contreras, L. Hare, B. Camarena, D. Glahn, Albana M Dassori, R. Medina, S. Contreras, M. Ramirez, R. Armas, R. Munoz, R. Mendoza, H. Raventos, A. Ontiveros, H. Nicolini, R. Palmer, M. Escamilla

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalActa Psychiatrica Scandinavica
Volume119
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • Depression
  • Psychosis
  • Serotonin transporter polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health

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