The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders

J. Contreras, L. Hare, B. Camarena, D. Glahn, A. Dassori, R. Medina, S. Contreras, M. Ramirez, R. Armas, R. Munoz, R. Mendoza, H. Raventos, A. Ontiveros, H. Nicolini, R. Palmer, M. Escamilla

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalActa Psychiatrica Scandinavica
Volume119
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • Depression
  • Psychosis
  • Serotonin transporter polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health

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