The Ser(326)cys polymorphism of 8-oxoguanine glycosylase 1 (ogg1) is associated with type 2 diabetes in mexican Americans

Farook Thameem, Sobha Puppala, Donna M Lehman, Michael P. Stern, John Blangero, Hanna E. Abboud, Ravindranath Duggirala, Samy L Habib

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: Human 8-oxoguanine glycosylase 1 (OGG1) excises oxidatively damaged promutagenic base 8-oxoguanine, a lesion previously observed in a rat model of type 2 diabetes (T2DM). The objective of the present study is to determine whether genetic variation in OGG1 is associated with type 2 diabetes (T2DM) in a Mexican American cohort. Methods: Ten SNPs including two tagging SNPs (rs1052133, rs2072668) across the OGG1 gene region were selected from the Hapmap database and genotyped in the entire cohort (n = 670; 29% diabetes; 39 families) by TaqMan assay. Association analyses between the SNPs and T2DM were performed using the measured genotype approach as implemented in the program SOLAR. Results: Of the ten SNPs genotyped, only five were polymorphic. The minor allele frequencies of these 5 SNPs ranged from 1-38%. Of the SNPs examined for association, the Ser(326)Cys (rs1052133) exhibited significant association with T2DM (p = 0.016) after accounting for age and sex effects. Another intronic variant (rs2072668), which was in strong linkage disequilibrium (r2 = 0.96) with Ser(326)Cys also exhibited significant association with T2DM (p = 0.031). Conclusions: These results suggest for the first time that the variants in OGG1 could influence diabetes risk in these Mexican American families and support a role for alterations of OGG1 in the pathogenesis of T2DM.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalHuman Heredity
Volume70
Issue number2
DOIs
StatePublished - Jul 2010

Fingerprint

Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
HapMap Project
Linkage Disequilibrium
Gene Frequency
8-hydroxyguanine
Genotype
Databases
Genes

Keywords

  • Association
  • Mexican Americans
  • OGG1
  • rs1052133
  • Ser326Cys polymorphism
  • Tagging SNPs
  • Type 2 diabetes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

The Ser(326)cys polymorphism of 8-oxoguanine glycosylase 1 (ogg1) is associated with type 2 diabetes in mexican Americans. / Thameem, Farook; Puppala, Sobha; Lehman, Donna M; Stern, Michael P.; Blangero, John; Abboud, Hanna E.; Duggirala, Ravindranath; Habib, Samy L.

In: Human Heredity, Vol. 70, No. 2, 07.2010, p. 97-101.

Research output: Contribution to journalArticle

Thameem, F, Puppala, S, Lehman, DM, Stern, MP, Blangero, J, Abboud, HE, Duggirala, R & Habib, SL 2010, 'The Ser(326)cys polymorphism of 8-oxoguanine glycosylase 1 (ogg1) is associated with type 2 diabetes in mexican Americans', Human Heredity, vol. 70, no. 2, pp. 97-101. https://doi.org/10.1159/000291964
Thameem, Farook ; Puppala, Sobha ; Lehman, Donna M ; Stern, Michael P. ; Blangero, John ; Abboud, Hanna E. ; Duggirala, Ravindranath ; Habib, Samy L. / The Ser(326)cys polymorphism of 8-oxoguanine glycosylase 1 (ogg1) is associated with type 2 diabetes in mexican Americans. In: Human Heredity. 2010 ; Vol. 70, No. 2. pp. 97-101.
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abstract = "Objective: Human 8-oxoguanine glycosylase 1 (OGG1) excises oxidatively damaged promutagenic base 8-oxoguanine, a lesion previously observed in a rat model of type 2 diabetes (T2DM). The objective of the present study is to determine whether genetic variation in OGG1 is associated with type 2 diabetes (T2DM) in a Mexican American cohort. Methods: Ten SNPs including two tagging SNPs (rs1052133, rs2072668) across the OGG1 gene region were selected from the Hapmap database and genotyped in the entire cohort (n = 670; 29{\%} diabetes; 39 families) by TaqMan assay. Association analyses between the SNPs and T2DM were performed using the measured genotype approach as implemented in the program SOLAR. Results: Of the ten SNPs genotyped, only five were polymorphic. The minor allele frequencies of these 5 SNPs ranged from 1-38{\%}. Of the SNPs examined for association, the Ser(326)Cys (rs1052133) exhibited significant association with T2DM (p = 0.016) after accounting for age and sex effects. Another intronic variant (rs2072668), which was in strong linkage disequilibrium (r2 = 0.96) with Ser(326)Cys also exhibited significant association with T2DM (p = 0.031). Conclusions: These results suggest for the first time that the variants in OGG1 could influence diabetes risk in these Mexican American families and support a role for alterations of OGG1 in the pathogenesis of T2DM.",
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AU - Stern, Michael P.

AU - Blangero, John

AU - Abboud, Hanna E.

AU - Duggirala, Ravindranath

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