The selenium and vitamin E cancer prevention trial

Eric A. Klein; Scott M. Lippman; Ian M. Thompson; Phyllis J. Goodman; Demetrius Albanes; Philip R. Taylor; Charles Coltman

doi:10.1007/s00345-002-0314-z

The selenium and vitamin E cancer prevention trial

Eric A. Klein, Scott M. Lippman, Ian M. Thompson, Phyllis J. Goodman, Demetrius Albanes, Philip R. Taylor, Charles Coltman

Mays Cancer Center

Research output: Contribution to journal › Review article

87 Scopus citations

Abstract

Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.

Original language	English (US)
Pages (from-to)	21-27
Number of pages	7
Journal	World Journal of Urology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s00345-002-0314-z
State	Published - May 1 2003

Fingerprint

Keywords

Chemoprevention
Prostate cancer
Selenium
Vitamin E

ASJC Scopus subject areas

Urology

Cite this

Klein, E. A., Lippman, S. M., Thompson, I. M., Goodman, P. J., Albanes, D., Taylor, P. R., & Coltman, C. (2003). The selenium and vitamin E cancer prevention trial. World Journal of Urology, 21(1), 21-27. https://doi.org/10.1007/s00345-002-0314-z

@article{ff9b408036b549a8a7f9d8bb6971f673,

title = "The selenium and vitamin E cancer prevention trial",

abstract = "Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.",

keywords = "Chemoprevention, Prostate cancer, Selenium, Vitamin E",

author = "Klein, {Eric A.} and Lippman, {Scott M.} and Thompson, {Ian M.} and Goodman, {Phyllis J.} and Demetrius Albanes and Taylor, {Philip R.} and Charles Coltman",

year = "2003",

month = may,

day = "1",

doi = "10.1007/s00345-002-0314-z",

language = "English (US)",

volume = "21",

pages = "21--27",

journal = "World Journal of Urology",

issn = "0724-4983",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - The selenium and vitamin E cancer prevention trial

AU - Klein, Eric A.

AU - Lippman, Scott M.

AU - Thompson, Ian M.

AU - Goodman, Phyllis J.

AU - Albanes, Demetrius

AU - Taylor, Philip R.

AU - Coltman, Charles

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.

AB - Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.

KW - Chemoprevention

KW - Prostate cancer

KW - Selenium

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=0141958547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141958547&partnerID=8YFLogxK

U2 - 10.1007/s00345-002-0314-z

DO - 10.1007/s00345-002-0314-z

M3 - Review article

C2 - 12756490

AN - SCOPUS:0141958547

VL - 21

SP - 21

EP - 27

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 1

ER -

Access to Document

10.1007/s00345-002-0314-z