Abstract
Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-27 |
| Number of pages | 7 |
| Journal | World Journal of Urology |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 2003 |
Fingerprint
Keywords
- Chemoprevention
- Prostate cancer
- Selenium
- Vitamin E
ASJC Scopus subject areas
- Urology
Cite this
The selenium and vitamin E cancer prevention trial. / Klein, Eric A.; Lippman, Scott M.; Thompson, Ian M.; Goodman, Phyllis J.; Albanes, Demetrius; Taylor, Philip R.; Coltman, Charles.
In: World Journal of Urology, Vol. 21, No. 1, 05.2003, p. 21-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The selenium and vitamin E cancer prevention trial
AU - Klein, Eric A.
AU - Lippman, Scott M.
AU - Thompson, Ian M.
AU - Goodman, Phyllis J.
AU - Albanes, Demetrius
AU - Taylor, Philip R.
AU - Coltman, Charles
PY - 2003/5
Y1 - 2003/5
N2 - Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.
AB - Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.
KW - Chemoprevention
KW - Prostate cancer
KW - Selenium
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=0141958547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141958547&partnerID=8YFLogxK
U2 - 10.1081/MA-120016671
DO - 10.1081/MA-120016671
M3 - Article
VL - 21
SP - 21
EP - 27
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 1
ER -