Abstract
Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results: Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.
Original language | English (US) |
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Pages (from-to) | 21-27 |
Number of pages | 7 |
Journal | World Journal of Urology |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - May 1 2003 |
Keywords
- Chemoprevention
- Prostate cancer
- Selenium
- Vitamin E
ASJC Scopus subject areas
- Urology