The role of tumor necrosis factor receptor type 1 in orthodontic tooth movement

I. Andrade, T. A. Silva, G. A.B. Silva, A. L. Teixeira, M. M. Teixeira

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-α plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and p55-deficient mice (p55-/-). Levels of TNF-α and 2 chemokines (MCP-1/CCL2, RANTES/CCL5) were evaluated in periodontal tissues. A significant increase in CCL2 and TNF-α was observed in both groups after 12 hrs of mechanical loading. However, CCL5 levels remained unchanged in p55-/- mice at this time-point. The number of TRAP-positive osteoclasts in p55-/- mice was significantly lower than that in WT mice. Also, there was a significantly smaller rate of tooth movement in p55-/- mice. Analysis of our data suggests that the TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.

Original languageEnglish (US)
Pages (from-to)1089-1094
Number of pages6
JournalJournal of dental research
Issue number11
StatePublished - Nov 2007
Externally publishedYes


  • Bone remodeling
  • Chemokines
  • Mechanical loading
  • Orthodontic tooth movement
  • TNF-α

ASJC Scopus subject areas

  • General Dentistry


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