TY - JOUR
T1 - The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
AU - Kaklamani, Virginia
AU - Yi, Nengjun
AU - Sadim, Maureen
AU - Siziopikou, Kalliopi
AU - Zhang, Kui
AU - Xu, Yanfei
AU - Tofilon, Sarah
AU - Agarwal, Surbhi
AU - Pasche, Boris
AU - Mantzoros, Christos
N1 - Funding Information:
This work was supported by the Walter S. Mander Foundation, Chicago, IL, the Lynn Sage Foundation, Chicago, IL, the Lynn Sage Scholar Award, Chicago, IL (Kaklamani); R01 CA112520 (Pasche), R01-GM74913 (Zhang) and 2R01GM069430-06 (Yi). In loving memory of Dolores Knes, who reminds us every day that the goal of our research is to improve the lives of our patients.
PY - 2011/4/13
Y1 - 2011/4/13
N2 - Background: Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity. Our objective was to evaluate tissue expression of FTO in breast and the role of FTO SNPs in predicting breast cancer risk.Methods: We performed a case-control study of 354 breast cancer cases and 364 controls. This study was conducted at Northwestern University. We examined the role of single nucleotide polymorphisms (SNPs) of intron 1 of FTO in breast cancer risk. We genotyped cases and controls for four SNPs: rs7206790, rs8047395, rs9939609 and rs1477196. We also evaluated tissue expression of FTO in normal and malignant breast tissue.Results: We found that all SNPs were significantly associated with breast cancer risk with rs1477196 showing the strongest association. We showed that FTO is expressed both in normal and malignant breast tissue. We found that FTO genotypes provided powerful classifiers to predict breast cancer risk and a model with epistatic interactions further improved the prediction accuracy with a receiver operating characteristic (ROC) curves of 0.68.Conclusion: In conclusion we have shown a significant expression of FTO in malignant and normal breast tissue and that FTO SNPs in intron 1 are significantly associated with breast cancer risk. Furthermore, these FTO SNPs are powerful classifiers in predicting breast cancer risk.
AB - Background: Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity. Our objective was to evaluate tissue expression of FTO in breast and the role of FTO SNPs in predicting breast cancer risk.Methods: We performed a case-control study of 354 breast cancer cases and 364 controls. This study was conducted at Northwestern University. We examined the role of single nucleotide polymorphisms (SNPs) of intron 1 of FTO in breast cancer risk. We genotyped cases and controls for four SNPs: rs7206790, rs8047395, rs9939609 and rs1477196. We also evaluated tissue expression of FTO in normal and malignant breast tissue.Results: We found that all SNPs were significantly associated with breast cancer risk with rs1477196 showing the strongest association. We showed that FTO is expressed both in normal and malignant breast tissue. We found that FTO genotypes provided powerful classifiers to predict breast cancer risk and a model with epistatic interactions further improved the prediction accuracy with a receiver operating characteristic (ROC) curves of 0.68.Conclusion: In conclusion we have shown a significant expression of FTO in malignant and normal breast tissue and that FTO SNPs in intron 1 are significantly associated with breast cancer risk. Furthermore, these FTO SNPs are powerful classifiers in predicting breast cancer risk.
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U2 - 10.1186/1471-2350-12-52
DO - 10.1186/1471-2350-12-52
M3 - Article
C2 - 21489227
AN - SCOPUS:79953842952
SN - 1755-8794
VL - 12
JO - BMC Medical Genetics
JF - BMC Medical Genetics
M1 - 52
ER -