The role of the amygdala in bipolar disorder development

Amy Garrett, Kiki Chang

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development.

Original languageEnglish (US)
Pages (from-to)1285-1296
Number of pages12
JournalDevelopment and Psychopathology
Volume20
Issue number4
DOIs
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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