The role of synaptic reorganization in mesial temporal lobe epilepsy

Jose E. Cavazos, Devin J. Cross

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

The mechanisms underlying mesial temporal lobe epilepsy (MTLE) remain uncertain. Putative mechanisms should account for several features characteristic of the clinical presentation and the neurophysiological and neuropathological abnormalities observed in patients with intractable MTLE. Synaptic reorganization of the mossy fiber pathway has received considerable attention over the past two decades as a potential mechanism that increases the excitability of the hippocampal network through the formation of new recurrent excitatory collaterals. Morphological plasticity beyond the mossy fiber pathway has not been as thoroughly investigated. Recently, plasticity of the CA1 pyramidal axons has been demonstrated in acute and chronic experimental models of MTLE. As the hippocampal formation is topographically organized in stacks of slices (lamellae), synaptic reorganization of CA1 axons projecting to subiculum appears to increase the connectivity between lamellae, providing a mechanism for translamellar synchronization of cellular hyperexcitability, leading to pharmacologically intractable seizures.

Original languageEnglish (US)
Pages (from-to)483-493
Number of pages11
JournalEpilepsy and Behavior
Volume8
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Epileptogenesis
  • Hippocampus
  • Mechanisms
  • Seizures
  • Sprouting

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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