The role of statins as potential targets for bone formation

I. Ross Garrett, Greg R. Mundy

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene expression of bone morphogenetic protein-2, which is an autocrine-paracrine factor for osteoblast differentiation. The findings that statins increase bone formation and bone mass in rodents suggest a potential new action for these compounds, which may be beneficial in patients with established osteoporosis where marked bone loss has occurred. Recent clinical data suggest that they may reduce the risk of fracture in patients taking these drugs.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalArthritis Research
Volume4
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Bone formation
  • HMG-CoA reductase
  • Inhibitors
  • Osteoblasts
  • Osteoporosis
  • Statins

ASJC Scopus subject areas

  • Rheumatology

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