The role of skin painting in predicting lung cancer

Z. Walaszek, M. Hanausek, Thomas J Slaga

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The mouse skin cancer model provides an important system for studying mechanisms involved in the various stages of carcinogenesis and for bioassaying tobacco smoke constituents and additives for carcinogenic/cocarcinogenic and tumor-promoting properties as well as for identifying compounds that may inhibit tumor formation and malignant conversion. In addition, it is an excellent model for studying the formation of precancerous lesions as well as squamous cell carcinomas. It relates very well to other squamous cell carcinoma models and contributes to better understanding of the human epithelial cancers including lung cancer. The SENCAR mouse is an established model system demonstrated to be more sensitive than the B6C3F1 or Swiss CD-1 strains in the initiation/promotion skin-painting test method. Although the relationship between mouse skin tumors and any manifestation of the toxicity of tobacco smoke and other complex environmental mixtures in humans is unknown, the skin-painting model is the only assay that provides a practical method of obtaining a tumorigenic end point with cigarette smoke condensates and other complex mixtures. This assay provides a rapid response with relative ease of quantification of various parameters of tumorigenic response including tumor incidence, latency, multiplicity, and malignancy.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalInternational Journal of Toxicology
Volume26
Issue number4
DOIs
StatePublished - Jul 2007

Fingerprint

Paintings
Painting
Lung Neoplasms
Skin
Tumors
Smoke
Tobacco
Neoplasms
Complex Mixtures
Squamous Cell Carcinoma
Assays
Inbred SENCAR Mouse
Skin Neoplasms
Skin Tests
Tobacco Products
Toxicity
Carcinogenesis
Incidence

Keywords

  • Lung Cancer Prediction
  • Skin Carcinogenesis
  • Skin Painting

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

The role of skin painting in predicting lung cancer. / Walaszek, Z.; Hanausek, M.; Slaga, Thomas J.

In: International Journal of Toxicology, Vol. 26, No. 4, 07.2007, p. 345-351.

Research output: Contribution to journalArticle

Walaszek, Z. ; Hanausek, M. ; Slaga, Thomas J. / The role of skin painting in predicting lung cancer. In: International Journal of Toxicology. 2007 ; Vol. 26, No. 4. pp. 345-351.
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