TY - JOUR
T1 - The role of platelet-activating factor receptor (PAFR) in lung pathology during experimental malaria
AU - Lacerda-Queiroz, Norinne
AU - Rachid, Milene Alvarenga
AU - Teixeira, Mauro Martins
AU - Teixeira, Antonio Lucio
PY - 2013/1
Y1 - 2013/1
N2 - Malaria-associated lung pathology has been a neglected area in the study of malaria complications. Platelet-activating factor (PAF) is an inflammatory mediator involved in lung inflammation. Using mice lacking the PAF receptor (PAFR-/-) we investigated the relevance of signaling through the PAFR for the lung inflammatory process triggered by Plasmodium berghei ANKA (PbA) strain infection. In PAFR-/- mice, pulmonary inflammation was markedly reduced as demonstrated by histology, production of certain pro-inflammatory mediators, accumulation of macrophage and CD8+ T cells in the lung parenchyma and the virtual absence of changes in vascular permeability. Therefore, PAFR activation is crucial in the pathogenesis of pulmonary damage associated with PbA infection in C57Bl/6 mice.
AB - Malaria-associated lung pathology has been a neglected area in the study of malaria complications. Platelet-activating factor (PAF) is an inflammatory mediator involved in lung inflammation. Using mice lacking the PAF receptor (PAFR-/-) we investigated the relevance of signaling through the PAFR for the lung inflammatory process triggered by Plasmodium berghei ANKA (PbA) strain infection. In PAFR-/- mice, pulmonary inflammation was markedly reduced as demonstrated by histology, production of certain pro-inflammatory mediators, accumulation of macrophage and CD8+ T cells in the lung parenchyma and the virtual absence of changes in vascular permeability. Therefore, PAFR activation is crucial in the pathogenesis of pulmonary damage associated with PbA infection in C57Bl/6 mice.
KW - Lung
KW - Malaria
KW - Mouse model
KW - Plasmodium berghei ANKA
KW - Platelet-activating factor receptor
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U2 - 10.1016/j.ijpara.2012.11.008
DO - 10.1016/j.ijpara.2012.11.008
M3 - Article
C2 - 23260771
AN - SCOPUS:84872386797
SN - 0020-7519
VL - 43
SP - 11
EP - 15
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 1
ER -