The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Ala Y. Issa, Suresh R. Volate, Michael J Wargovich

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.

Original languageEnglish (US)
Pages (from-to)405-419
Number of pages15
JournalJournal of Food Composition and Analysis
Volume19
Issue number5
DOIs
StatePublished - Aug 2006
Externally publishedYes

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Phytochemicals
phytopharmaceuticals
inflammation
Inflammation
neoplasms
Cardiovascular Abnormalities
Neoplasms
chronic diseases
molecular biology
herbs
Molecular Biology
Chronic Disease
researchers
Research Personnel
Guidelines
therapeutics
Direction compound
Therapeutics
methodology

Keywords

  • Antioxidants
  • Cell signaling pathways
  • Chemoprevention
  • COX-2
  • Dietary supplements
  • Herbs
  • Inflammation
  • iNOS
  • Phase II enzymes
  • Phytochemicals

ASJC Scopus subject areas

  • Food Science

Cite this

The role of phytochemicals in inhibition of cancer and inflammation : New directions and perspectives. / Issa, Ala Y.; Volate, Suresh R.; Wargovich, Michael J.

In: Journal of Food Composition and Analysis, Vol. 19, No. 5, 08.2006, p. 405-419.

Research output: Contribution to journalArticle

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