Abstract
Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-419 |
| Number of pages | 15 |
| Journal | Journal of Food Composition and Analysis |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 2006 |
| Externally published | Yes |
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Keywords
- Antioxidants
- Cell signaling pathways
- Chemoprevention
- COX-2
- Dietary supplements
- Herbs
- Inflammation
- iNOS
- Phase II enzymes
- Phytochemicals
ASJC Scopus subject areas
- Food Science
Cite this
The role of phytochemicals in inhibition of cancer and inflammation : New directions and perspectives. / Issa, Ala Y.; Volate, Suresh R.; Wargovich, Michael J.
In: Journal of Food Composition and Analysis, Vol. 19, No. 5, 08.2006, p. 405-419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of phytochemicals in inhibition of cancer and inflammation
T2 - New directions and perspectives
AU - Issa, Ala Y.
AU - Volate, Suresh R.
AU - Wargovich, Michael J
PY - 2006/8
Y1 - 2006/8
N2 - Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.
AB - Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.
KW - Antioxidants
KW - Cell signaling pathways
KW - Chemoprevention
KW - COX-2
KW - Dietary supplements
KW - Herbs
KW - Inflammation
KW - iNOS
KW - Phase II enzymes
KW - Phytochemicals
UR - http://www.scopus.com/inward/record.url?scp=33747452321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747452321&partnerID=8YFLogxK
U2 - 10.1016/j.jfca.2006.02.009
DO - 10.1016/j.jfca.2006.02.009
M3 - Article
VL - 19
SP - 405
EP - 419
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
SN - 0889-1575
IS - 5
ER -