The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Ala Y. Issa; Suresh R. Volate; Michael J. Wargovich

doi:10.1016/j.jfca.2006.02.009

The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Ala Y. Issa, Suresh R. Volate, Michael J. Wargovich

Research output: Contribution to journal › Review article › peer-review

107 Scopus citations

Abstract

Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.

Original language	English (US)
Pages (from-to)	405-419
Number of pages	15
Journal	Journal of Food Composition and Analysis
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.jfca.2006.02.009
State	Published - Aug 1 2006
Externally published	Yes

Keywords

Antioxidants
COX-2
Cell signaling pathways
Chemoprevention
Dietary supplements
Herbs
Inflammation
Phase II enzymes
Phytochemicals
iNOS

ASJC Scopus subject areas

Food Science

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10.1016/j.jfca.2006.02.009

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abstract = "Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.",

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AU - Wargovich, Michael J.

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AB - Herbs have been utilized to treat acute and chronic disorders for thousands of years. The scientific basis for such utilization, however, has been poorly understood. Nonetheless, in the past few decades, significant advances in experimental methodology and molecular biology enabled researchers to investigate the potential use of phytochemicals to treat or manage a plethora of chronic diseases including various types of cancer, inflammatory diseases and cardiovascular abnormalities. This review summarizes some of the molecular mechanisms through which several phytochemicals may inhibit inflammation and cancer. In addition, the review discusses basic definitions, ethical and clinical aspects and some guidelines for the use of phytochemicals as chemopreventive or therapeutic agents.

KW - Antioxidants

KW - COX-2

KW - Cell signaling pathways

KW - Chemoprevention

KW - Dietary supplements

KW - Herbs

KW - Inflammation

KW - Phase II enzymes

KW - Phytochemicals

KW - iNOS

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The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Abstract

Keywords

ASJC Scopus subject areas

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