The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation

Andrew D. Burdick, Dae J. Kim, Marjorie A. Peraza, Frank J. Gonzalez, Jeffrey M. Peters

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The physiological and pharmacological roles of peroxisome proliferator-activated receptor-β (PPARβ-also referred to as PPARδ) are just beginning to emerge. It has recently become clear that PPARβ has a function in epithelial tissues, but controversy exists due to inconsistencies in the literature. There is strong evidence that ligand activation of PPARβ can induce terminal differentiation of keratinocytes, with a concomitant inhibition of cell proliferation. However, the role of PPARβ in keratinocyte-specific apoptosis is less clear. Additionally, the role of PPARβ in colonic epithelium remains unclear due to conflicting evidence suggesting that ligand activation of PPARβ can potentiate, as well as attenuate, intestinal cancer. Recent studies revealed that ligand activation of PPARβ can induce fatty acid catabolism in skeletal muscle and is associated with improved insulin sensitivity, attenuated weight gain and elevated HDL levels thus demonstrating promising potential for targeting PPARβ for treating obesity, dyslipidemias and type 2 diabetes. Therefore, it becomes critical to determine the safety of PPARβ ligands. This review focuses on recent literature describing the role of PPARβ in epithelial tissues and highlights critical discrepancies that need to be resolved for a more comprehensive understanding of how this receptor modulates epithelial homeostasis.

Original languageEnglish (US)
Pages (from-to)9-20
Number of pages12
JournalCellular Signalling
Volume18
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Peroxisome Proliferator-Activated Receptors
Cell Differentiation
Epithelial Cells
Growth
Ligands
Epithelium
Keratinocytes
Intestinal Neoplasms
Dyslipidemias
Type 2 Diabetes Mellitus
Weight Gain
Insulin Resistance
Skeletal Muscle
Homeostasis
Fatty Acids
Obesity

Keywords

  • Apoptosis
  • Cancer
  • Cell proliferation
  • Differentiation
  • Epithelium
  • Peroxisome proliferator-activated receptor-β/δ
  • PPARβ/δ
  • Skin

ASJC Scopus subject areas

  • Cell Biology

Cite this

The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation. / Burdick, Andrew D.; Kim, Dae J.; Peraza, Marjorie A.; Gonzalez, Frank J.; Peters, Jeffrey M.

In: Cellular Signalling, Vol. 18, No. 1, 01.2006, p. 9-20.

Research output: Contribution to journalArticle

Burdick, Andrew D. ; Kim, Dae J. ; Peraza, Marjorie A. ; Gonzalez, Frank J. ; Peters, Jeffrey M. / The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation. In: Cellular Signalling. 2006 ; Vol. 18, No. 1. pp. 9-20.
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