The role of oxidative damage and stress in aging

Alex Bokov, Asish Chaudhuri, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

443 Scopus citations

Abstract

The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various biomolecules increases with age, and caloric restriction, which increases life span and retards aging, reduces the age-related increase in oxidative damage to biomolecules. The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span. For the first time, investigators can use genetically altered animals to test directly the role of oxidative damage in aging. In this manuscript, we critically review the past research in this area and discuss potential future research directions in testing the Free Radical/Oxidative Theory of Aging.

Original languageEnglish (US)
Pages (from-to)811-826
Number of pages16
JournalMechanisms of Ageing and Development
Volume125
Issue number10-11 SPEC. ISS.
DOIs
StatePublished - Jan 1 2004

Keywords

  • Antioxidants
  • Free radicals
  • Oxidative damage
  • Oxidative stress

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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