Abstract
Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.
Original language | English (US) |
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Pages (from-to) | 360-365 |
Number of pages | 6 |
Journal | Microbes and Infection |
Volume | 22 |
Issue number | 8 |
DOIs | |
State | Published - Sep 2020 |
Keywords
- Bacterial burdens
- Chlamydia sp
- Gene regulation
- IFN-γ
- Lung
- miR-155
- microRNA
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases