The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs

Jonathon Keck; James P. Chambers; Aravind Kancharla; Dona Haj Bashir; Laura Henley; Katherine Schenkel; Kevin Castillo; M. Neal Guentzel; Rishein Gupta; Bernard P. Arulanandam

doi:10.1016/j.micinf.2020.02.005

The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs

Jonathon Keck, James P. Chambers, Aravind Kancharla, Dona Haj Bashir, Laura Henley, Katherine Schenkel, Kevin Castillo, M. Neal Guentzel, Rishein Gupta, Bernard P. Arulanandam

Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

Abstract

Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.

Original language	English (US)
Pages (from-to)	360-365
Number of pages	6
Journal	Microbes and Infection
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.micinf.2020.02.005
State	Published - Sep 2020

Keywords

Bacterial burdens
Chlamydia sp
Gene regulation
IFN-γ
Lung
miR-155
microRNA

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs. / Keck, Jonathon; Chambers, James P.; Kancharla, Aravind; Bashir, Dona Haj; Henley, Laura; Schenkel, Katherine; Castillo, Kevin; Neal Guentzel, M.; Gupta, Rishein; Arulanandam, Bernard P.

In: Microbes and Infection, Vol. 22, No. 8, 09.2020, p. 360-365.

Research output: Contribution to journal › Article › peer-review

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abstract = "Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.",

keywords = "Bacterial burdens, Chlamydia sp, Gene regulation, IFN-γ, Lung, miR-155, microRNA",

author = "Jonathon Keck and Chambers, {James P.} and Aravind Kancharla and Bashir, {Dona Haj} and Laura Henley and Katherine Schenkel and Kevin Castillo and {Neal Guentzel}, M. and Rishein Gupta and Arulanandam, {Bernard P.}",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH) grant IR03AI11771401A1 , and the Army Research Office (Department of Defense contract No. W911NF-11-1-0136 ). ",

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AU - Bashir, Dona Haj

AU - Henley, Laura

AU - Schenkel, Katherine

AU - Castillo, Kevin

AU - Neal Guentzel, M.

AU - Gupta, Rishein

AU - Arulanandam, Bernard P.

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