The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs

Jonathon Keck, James P. Chambers, Aravind Kancharla, Dona Haj Bashir, Laura Henley, Katherine Schenkel, Kevin Castillo, M. Neal Guentzel, Rishein Gupta, Bernard P. Arulanandam

Research output: Contribution to journalArticlepeer-review

Abstract

Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalMicrobes and Infection
Volume22
Issue number8
DOIs
StatePublished - Sep 2020

Keywords

  • Bacterial burdens
  • Chlamydia sp
  • Gene regulation
  • IFN-γ
  • Lung
  • miR-155
  • microRNA

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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