The role of mating type and morphology in Cryptococcus neoformans pathogenesis

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Cryptococcus neoformans is a major fungal pathogen of both humans and animals. The fungus can be divided into two varieties, with each variety being composed of two serotypes. A sexual phase has been identified, which classifies C. neoformans as a bipolar heterothallic fungus with two mating types, MATa and MATα. The analysis of mating and mating type in this organism is important for a number of reasons. Both clinical and environmental isolates display a severe bias of the MATα mating type over MATa. MATα cells are also more virulent than MATα cells. Molecular and genetic analyses of the genes that make up the mating pathway have revealed that some of these genes are required for virulence. Finally, although it is well known that infection begins in the lungs after inhalation of infectious particles, it still remains unclear what constitutes the infectious particle. This review will discuss current information about what is known about the role that mating type and morphology play in virulence.

Original languageEnglish (US)
Pages (from-to)313-329
Number of pages17
JournalInternational Journal of Medical Microbiology
Volume292
Issue number5-6
DOIs
StatePublished - Oct 2002

Keywords

  • Cryptococcus neoformans
  • Mating types
  • Morphology
  • Pathogenesis
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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