The role of macromolecular damage in aging and age-related disease

Arlan G. Richardson, Eric E. Schadt

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Several decades of research have shown that macromolecular damage increases with age and that damage to protein, DNA, lipids, and other macromolecular components appears to be important factors in specific age-related diseases. The strongest evidence that macromolecular damage is a causative factor in aging comes from studies using manipulations that increase life span. However, it is currently unclear whether damage to macromolecules plays a role in the actual processes of aging. In other words, is macromolecular damage driven by aging or is it that damage to a key molecular component directly causes aging?

Original languageEnglish (US)
Pages (from-to)S28-S32
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

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Lipids
DNA
Research
Proteins

Keywords

  • DNA oxidative damage
  • Oxidative stress
  • Protein oxidative damage

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

The role of macromolecular damage in aging and age-related disease. / Richardson, Arlan G.; Schadt, Eric E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69, 01.06.2014, p. S28-S32.

Research output: Contribution to journalArticle

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