The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Alexei V. Tumanov; Dmitry V. Kuprash; Sergei A. Nedospasov

doi:10.1016/S1359-6101(03)00026-1

The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Alexei V. Tumanov, Dmitry V. Kuprash, Sergei A. Nedospasov

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

Original language	English (US)
Pages (from-to)	275-288
Number of pages	14
Journal	Cytokine and Growth Factor Reviews
Volume	14
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-6101(03)00026-1
State	Published - Jan 1 2003
Externally published	Yes

Keywords

Lymphoid organogenesis
Lymphotoxin
Secondary lymphoid organs
Tumor necrosis factor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S1359-6101(03)00026-1

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AU - Kuprash, Dmitry V.

AU - Nedospasov, Sergei A.

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N2 - Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

AB - Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

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KW - Lymphotoxin

KW - Secondary lymphoid organs

KW - Tumor necrosis factor

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