The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Alexei V. Tumanov; Dmitry V. Kuprash; Sergei A. Nedospasov

doi:10.1016/S1359-6101(03)00026-1

The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Alexei V. Tumanov, Dmitry V. Kuprash, Sergei A. Nedospasov

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

Original language	English (US)
Pages (from-to)	275-288
Number of pages	14
Journal	Cytokine and Growth Factor Reviews
Volume	14
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-6101(03)00026-1
State	Published - 2003
Externally published	Yes

Keywords

Lymphoid organogenesis
Lymphotoxin
Secondary lymphoid organs
Tumor necrosis factor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S1359-6101(03)00026-1

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title = "The role of lymphotoxin in development and maintenance of secondary lymphoid tissues",

abstract = "Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.",

keywords = "Lymphoid organogenesis, Lymphotoxin, Secondary lymphoid organs, Tumor necrosis factor",

author = "Tumanov, {Alexei V.} and Kuprash, {Dmitry V.} and Nedospasov, {Sergei A.}",

note = "Funding Information: We are grateful to Dr. R.M. Hoffman for critical reading of the manuscript. A.V.T. and D.V.K. acknowledge support from Russian Foundation of Basic Research. A.V.T. was supported by ICRETT fellowship from the International Union Against Cancer. S.A.N. is an International Research Scholar of the Howard Hughes Medical Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.",

year = "2003",

doi = "10.1016/S1359-6101(03)00026-1",

language = "English (US)",

volume = "14",

pages = "275--288",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

number = "3-4",

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T1 - The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

AU - Tumanov, Alexei V.

AU - Kuprash, Dmitry V.

AU - Nedospasov, Sergei A.

N1 - Funding Information: We are grateful to Dr. R.M. Hoffman for critical reading of the manuscript. A.V.T. and D.V.K. acknowledge support from Russian Foundation of Basic Research. A.V.T. was supported by ICRETT fellowship from the International Union Against Cancer. S.A.N. is an International Research Scholar of the Howard Hughes Medical Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

PY - 2003

Y1 - 2003

N2 - Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

AB - Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

KW - Lymphoid organogenesis

KW - Lymphotoxin

KW - Secondary lymphoid organs

KW - Tumor necrosis factor

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DO - 10.1016/S1359-6101(03)00026-1

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AN - SCOPUS:0037982575

VL - 14

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EP - 288

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 3-4

ER -

The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Abstract

Keywords

ASJC Scopus subject areas

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