Abstract
Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.
Original language | English (US) |
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Pages (from-to) | 275-288 |
Number of pages | 14 |
Journal | Cytokine and Growth Factor Reviews |
Volume | 14 |
Issue number | 3-4 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Keywords
- Lymphoid organogenesis
- Lymphotoxin
- Secondary lymphoid organs
- Tumor necrosis factor
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Immunology