The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Alexei V. Tumanov, Dmitry V. Kuprash, Sergei A. Nedospasov

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

Original languageEnglish (US)
Pages (from-to)275-288
Number of pages14
JournalCytokine and Growth Factor Reviews
Volume14
Issue number3-4
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Lymphoid organogenesis
  • Lymphotoxin
  • Secondary lymphoid organs
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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