Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen- specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.
- Lymphoid organogenesis
- Secondary lymphoid organs
- Tumor necrosis factor
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Biochemistry, Genetics and Molecular Biology(all)