The Role of Interleukin-18 in Renal Injury

Jeffrey A. Leslie, Kirstan K. Meldrum

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-γ-inducing factor, which induces interferon-γ production in T cells and natural killer cells. It is synthesized as a biologically inactive precursor, which requires cleavage into an active molecule by an intracellular cysteine protease similar to IL-1β. This review examines the pro-inflammatory role of IL-18 in various types of renal injury (i.e., endotoxemia, cisplatin toxicity, allograft rejection, and ischemia-reperfusion injury) and explores the integral role of IL-12 in IL-18 function and activity.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalJournal of Surgical Research
Issue number1
StatePublished - Mar 2008


  • apoptosis
  • interleukin-18
  • ischemia
  • rejection
  • renal injury
  • reperfusion
  • transplantation

ASJC Scopus subject areas

  • Surgery


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