The Role of Interleukin-18 in Renal Injury

Jeffrey A. Leslie; Kirstan K. Meldrum

doi:10.1016/j.jss.2007.03.037

The Role of Interleukin-18 in Renal Injury

Jeffrey A. Leslie, Kirstan K. Meldrum

Department of Urology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-γ-inducing factor, which induces interferon-γ production in T cells and natural killer cells. It is synthesized as a biologically inactive precursor, which requires cleavage into an active molecule by an intracellular cysteine protease similar to IL-1β. This review examines the pro-inflammatory role of IL-18 in various types of renal injury (i.e., endotoxemia, cisplatin toxicity, allograft rejection, and ischemia-reperfusion injury) and explores the integral role of IL-12 in IL-18 function and activity.

Original language	English (US)
Pages (from-to)	170-175
Number of pages	6
Journal	Journal of Surgical Research
Volume	145
Issue number	1
DOIs	https://doi.org/10.1016/j.jss.2007.03.037
State	Published - Mar 2008

Keywords

apoptosis
interleukin-18
ischemia
rejection
renal injury
reperfusion
transplantation

ASJC Scopus subject areas

Surgery

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10.1016/j.jss.2007.03.037

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KW - rejection

KW - renal injury

KW - reperfusion

KW - transplantation

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The Role of Interleukin-18 in Renal Injury

Abstract

Keywords

ASJC Scopus subject areas

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