The role of insulin and insulin-like growth factor-I in mammalian ageing

Arlan Richardson; Feng Liu; Martin L. Adamo; Holly Van Remmen; James F. Nelson

doi:10.1016/j.beem.2004.02.002

The role of insulin and insulin-like growth factor-I in mammalian ageing

Arlan Richardson
, Feng Liu
, Martin L. Adamo
, Holly Van Remmen
, James F. Nelson

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard ageing. In this chapter, we describe the current research in mammalian systems with respect to the role of insulin or IGF-I in ageing. Using rodent models of caloric restriction and genetic mouse models, e.g. the Ames and Snell dwarf mice, fat-specific insulin receptor knockout mice (FIRKO) and mice that are heterozygous for the IGF-I receptor (Igf1r ^±), investigators have shown that a reduction in plasma levels of insulin and/or IGF-I or reductions in insulin/IGF-I signalling appear to be correlated with increased longevity and retarded ageing.

Original language	English (US)
Pages (from-to)	393-406
Number of pages	14
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.beem.2004.02.002
State	Published - Sep 2004

Keywords

Caloric restriction
Dwarf mice
Insulin
Insulin-like growth factor-I

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.beem.2004.02.002

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title = "The role of insulin and insulin-like growth factor-I in mammalian ageing",

abstract = "Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard ageing. In this chapter, we describe the current research in mammalian systems with respect to the role of insulin or IGF-I in ageing. Using rodent models of caloric restriction and genetic mouse models, e.g. the Ames and Snell dwarf mice, fat-specific insulin receptor knockout mice (FIRKO) and mice that are heterozygous for the IGF-I receptor (Igf1r ±), investigators have shown that a reduction in plasma levels of insulin and/or IGF-I or reductions in insulin/IGF-I signalling appear to be correlated with increased longevity and retarded ageing.",

keywords = "Caloric restriction, Dwarf mice, Insulin, Insulin-like growth factor-I",

author = "Arlan Richardson and Feng Liu and Adamo, \{Martin L.\} and \{Van Remmen\}, Holly and Nelson, \{James F.\}",

note = "Funding Information: This work was supported, in part, by the Environmental Hazards Center grant from the Department of Veteran Affairs and by the San Antonio Nathan Shock Ageing grant from the NIH.",

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AU - Liu, Feng

AU - Adamo, Martin L.

AU - Van Remmen, Holly

AU - Nelson, James F.

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The role of insulin and insulin-like growth factor-I in mammalian ageing

Abstract

Keywords

ASJC Scopus subject areas

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