The role of insulin and insulin-like growth factor-I in mammalian ageing

Arlan Richardson, Feng Liu, Martin L. Adamo, Holly Van Remmen, James F. Nelson

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard ageing. In this chapter, we describe the current research in mammalian systems with respect to the role of insulin or IGF-I in ageing. Using rodent models of caloric restriction and genetic mouse models, e.g. the Ames and Snell dwarf mice, fat-specific insulin receptor knockout mice (FIRKO) and mice that are heterozygous for the IGF-I receptor (Igf1r ±), investigators have shown that a reduction in plasma levels of insulin and/or IGF-I or reductions in insulin/IGF-I signalling appear to be correlated with increased longevity and retarded ageing.

Original languageEnglish (US)
Pages (from-to)393-406
Number of pages14
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Sep 2004


  • Caloric restriction
  • Dwarf mice
  • Insulin
  • Insulin-like growth factor-I

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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