The role of incretins in insulin secretion

Marzieh Salehi

doi:10.1007/978-3-319-18741-9_4

The role of incretins in insulin secretion

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The notion that gut factors produced in response to nutrient ingestion are capable of stimulating the endocrine pancreas and consequently reducing glycemic levels was introduced more than 100 years ago. These gut factors were subsequently called incretins, and the augmented insulin response to nutrient given orally compared to nutrient administered intravenously was named "incretin effect." This chapter focuses on the mechanisms of the synthesis and actions of the incretin peptides, glucagon-like peptide 1, and glucosedependent insulinotropic polypeptide. In addition, alteration in incretin axis in type 2 diabetes and therapeutic relevance of these peptides will be highlighted. Finally, the role of incretin axis in diabetes remission after gastrointestinal surgeries for treatment of obesity will be briefly discussed.

Original language	English (US)
Title of host publication	Principles of Diabetes Mellitus
Subtitle of host publication	Third Edition
Publisher	Springer International Publishing
Pages	57-69
Number of pages	13
ISBN (Electronic)	9783319187419
ISBN (Print)	9783319187402
DOIs	https://doi.org/10.1007/978-3-319-18741-9_4
State	Published - Jul 7 2017
Externally published	Yes

Keywords

Bariatric surgery
GIP
GLP-1
Incretin effect
Insulin secretion
Type 2 diabetes

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-319-18741-9_4

Cite this

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The role of incretins in insulin secretion

Abstract

Keywords

ASJC Scopus subject areas

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