TY - JOUR
T1 - The role of hypertension in the pathogenesis of heart failure
T2 - A clinical mechanistic overview
AU - Vasan, Ramachandran S.
AU - Levy, Daniel
PY - 1996/9/9
Y1 - 1996/9/9
N2 - Hypertension plays a key role in the evolution of the syndrome of heart failure. Hypertension has been identified as the chief precursor of left ventricular hypertrophy. Hypertensive left ventricular hypertrophy can lead to ventricular diastolic dysfunction; it is also a risk factor for myocardial infarction, which is a principal cause of left ventricular systolic dysfunction. Asymptomatic left ventricular dysfunction, whether systolic or diastolic, culminates in clinically overt heart failure when a threshold is exceeded or when other precipitating factors are superimposed. The onset of overt heart failure heralds a bleak outcome. These structural and functional changes associated with hypertension evolve over decades and are preventable with effective antihypertensive treatment. These observations emphasize the importance of early diagnosis and effective treatment of hypertension to prevent cardiac complications.
AB - Hypertension plays a key role in the evolution of the syndrome of heart failure. Hypertension has been identified as the chief precursor of left ventricular hypertrophy. Hypertensive left ventricular hypertrophy can lead to ventricular diastolic dysfunction; it is also a risk factor for myocardial infarction, which is a principal cause of left ventricular systolic dysfunction. Asymptomatic left ventricular dysfunction, whether systolic or diastolic, culminates in clinically overt heart failure when a threshold is exceeded or when other precipitating factors are superimposed. The onset of overt heart failure heralds a bleak outcome. These structural and functional changes associated with hypertension evolve over decades and are preventable with effective antihypertensive treatment. These observations emphasize the importance of early diagnosis and effective treatment of hypertension to prevent cardiac complications.
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U2 - 10.1001/archinte.156.16.1789
DO - 10.1001/archinte.156.16.1789
M3 - Review article
C2 - 8790072
AN - SCOPUS:0029793195
SN - 0003-9926
VL - 156
SP - 1789
EP - 1793
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 16
ER -