The role of hypertension in the pathogenesis of heart failure: A clinical mechanistic overview

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221 Scopus citations

Abstract

Hypertension plays a key role in the evolution of the syndrome of heart failure. Hypertension has been identified as the chief precursor of left ventricular hypertrophy. Hypertensive left ventricular hypertrophy can lead to ventricular diastolic dysfunction; it is also a risk factor for myocardial infarction, which is a principal cause of left ventricular systolic dysfunction. Asymptomatic left ventricular dysfunction, whether systolic or diastolic, culminates in clinically overt heart failure when a threshold is exceeded or when other precipitating factors are superimposed. The onset of overt heart failure heralds a bleak outcome. These structural and functional changes associated with hypertension evolve over decades and are preventable with effective antihypertensive treatment. These observations emphasize the importance of early diagnosis and effective treatment of hypertension to prevent cardiac complications.

Original languageEnglish (US)
Pages (from-to)1789-1793
Number of pages5
JournalArchives of Internal Medicine
Volume156
Issue number16
DOIs
StatePublished - Sep 9 1996
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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