The role of Hex in hemangioblast and hematopoietic development.

Rebecca J. Chan; Robert Hromas; Mervin C. Yoder

The role of Hex in hemangioblast and hematopoietic development.

Rebecca J. Chan, Robert Hromas, Mervin C. Yoder

Research output: Contribution to journal › Article › peer-review

Abstract

The orphan homeobox gene Hex has been shown to be critical for normal murine liver development using Hex-/- mice. Because of the early lethality of the Hex-/- mice, however, in vitro embryonic stem cell differentiation assays were employed to elucidate the role of Hex in murine hematopoiesis. These studies revealed that Hex is not required for hemangioblast development but is required in a dose-dependent fashion for hemangioblast differentiation to definitive hematopoietic progenitors. Contained here are the methods needed to conduct embryonic stem cell-derived in vitro hematopoietic assays.

Original language	English (US)
Pages (from-to)	123-133
Number of pages	11
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	330
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics

Cite this

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abstract = "The orphan homeobox gene Hex has been shown to be critical for normal murine liver development using Hex-/- mice. Because of the early lethality of the Hex-/- mice, however, in vitro embryonic stem cell differentiation assays were employed to elucidate the role of Hex in murine hematopoiesis. These studies revealed that Hex is not required for hemangioblast development but is required in a dose-dependent fashion for hemangioblast differentiation to definitive hematopoietic progenitors. Contained here are the methods needed to conduct embryonic stem cell-derived in vitro hematopoietic assays.",

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The role of Hex in hemangioblast and hematopoietic development.

Abstract

ASJC Scopus subject areas

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