The role of glycine in regulated cell death

Joel M. Weinberg, Anja Bienholz, M. A. Venkatachalam

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


The cytoprotective effects of glycine against cell death have been recognized for over 28 years. They are expressed in multiple cell types and injury settings that lead to necrosis, but are still not widely appreciated or considered in the conceptualization of cell death pathways. In this paper, we review the available data on the expression of this phenomenon, its relationship to major pathophysiologic pathways that lead to cell death and immunomodulatory effects, the hypothesis that it involves suppression by glycine of the development of a hydrophilic death channel of molecular dimensions in the plasma membrane, and evidence for its impact on disease processes in vivo.

Original languageEnglish (US)
Pages (from-to)2285-2308
Number of pages24
JournalCellular and Molecular Life Sciences
Issue number11-12
StatePublished - Jun 1 2016


  • Cell death
  • Cytoprotection
  • Glycine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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