The Role of Fixed-Dose Dual Bronchodilator Therapy in Treating COPD

Antonio R Anzueto, Marc Miravitlles

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The incidence of chronic obstructive pulmonary disease (COPD) is rising in the United States, and the disease represents a significant source of morbidity and mortality. Primary care providers face many challenges in COPD diagnosis and treatment, as different clinical phenotypes require personalized treatment approaches. Patient adherence and inhaler technique also contribute to treatment outcomes. Around 48% of primary care providers are unaware of guidelines and recommendations for COPD diagnosis and treatment, which may lead to misdiagnosis or undertreatment of COPD symptoms. Inadequately treated COPD can impair patients' quality of life and ability to perform everyday activities. Long-acting bronchodilator therapy is the cornerstone treatment for patients with COPD; combinations of bronchodilators of different pharmacological classes have shown improved efficacy vs monotherapy. We review the rationale behind fixed-dose dual bronchodilator therapy, evidence for the 4 currently Food and Drug Administration-approved long-acting anticholinergic bronchodilators/long-acting β2-agonists fixed combinations, patient suitability for the available inhaler devices, and practical guidance to optimize personalized care for patients with COPD.

Original languageEnglish (US)
JournalAmerican Journal of Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Bronchodilation
  • COPD
  • LABA
  • LAMA

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The Role of Fixed-Dose Dual Bronchodilator Therapy in Treating COPD'. Together they form a unique fingerprint.

  • Cite this