The role of echinocandins, extended-spectrum azoles, and polyenes to treat opportunistic moulds and Candida

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Three classes of antifungals - polyenes, extended-spectrum azoles, and echinocandins - are now available for treating systemic fungal infections. Guidance for the appropriate use of this expanded variety of antifungals may come from recent clinical trials. Extended-spectrum azoles have excellent in vitro activity against Aspergillus and have been shown to improve clinical outcomes. for Zygomycetes, along with the lipid formulations of amphotericin, of the new agents, only posaconazole has activity, For Candida, the echinocandins offer a broad spectrum of activity. These new agents offer less toxicity and potentially improved efficacy in these difficult infections.

Original languageEnglish (US)
Pages (from-to)442-448
Number of pages7
JournalCurrent Infectious Disease Reports
Volume8
Issue number6
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Infectious Diseases

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