TY - JOUR
T1 - The role of echinocandins, extended-spectrum azoles, and polyenes to treat opportunistic moulds and Candida
AU - Patterson, Thomas F.
PY - 2006/11
Y1 - 2006/11
N2 - Three classes of antifungals - polyenes, extended-spectrum azoles, and echinocandins - are now available for treating systemic fungal infections. Guidance for the appropriate use of this expanded variety of antifungals may come from recent clinical trials. Extended-spectrum azoles have excellent in vitro activity against Aspergillus and have been shown to improve clinical outcomes. for Zygomycetes, along with the lipid formulations of amphotericin, of the new agents, only posaconazole has activity, For Candida, the echinocandins offer a broad spectrum of activity. These new agents offer less toxicity and potentially improved efficacy in these difficult infections.
AB - Three classes of antifungals - polyenes, extended-spectrum azoles, and echinocandins - are now available for treating systemic fungal infections. Guidance for the appropriate use of this expanded variety of antifungals may come from recent clinical trials. Extended-spectrum azoles have excellent in vitro activity against Aspergillus and have been shown to improve clinical outcomes. for Zygomycetes, along with the lipid formulations of amphotericin, of the new agents, only posaconazole has activity, For Candida, the echinocandins offer a broad spectrum of activity. These new agents offer less toxicity and potentially improved efficacy in these difficult infections.
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U2 - 10.1007/s11908-006-0018-4
DO - 10.1007/s11908-006-0018-4
M3 - Review article
C2 - 17064637
AN - SCOPUS:33750872294
SN - 1523-3847
VL - 8
SP - 442
EP - 448
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 6
ER -