The role of connexin 43 in lung disease

Julie A. Swartzendruber, Bruce J. Nicholson, Ashlesh K. Murthy

Research output: Contribution to journalReview articlepeer-review

Abstract

The term lung disease describes a broad category of disorders that impair lung function. More than 35 million Americans have a preventable chronic lung disease with high mortality rates due to limited treatment efficacy. The recent increase in patients with lung disease highlights the need to increase our understanding of mechanisms driving lung inflammation. Connexins, gap junction proteins, and more specifically connexin 43 (Cx43), are abundantly expressed in the lung and are known to play a role in lung diseases. This review focuses on the role of Cx43 in pathology associated with acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD) and asthma. Additionally, we discuss the role of Cx43 in preventing disease through the transfer of mitochondria between cells. We aim to highlight the need to better understand what cell types are expressing Cx43 and how this expression influences lung disease.

Original languageEnglish (US)
Article number363
Pages (from-to)1-11
Number of pages11
JournalLife
Volume10
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Acute respiratory distress syndrome
  • Asthma
  • Connexin 43
  • Gap junction proteins
  • Mitochondria

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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