The role of comorbid psychiatric conditions in health status in epilepsy

John E. Zeber, Laurel A. Copeland, Megan Amuan, Joyce A. Cramer, Mary Jo V Pugh

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Comorbid psychiatric conditions are highly prevalent in patients with epilepsy, yet the long-term implications across multiple mental health conditions are poorly understood. We examined the association between psychiatric diagnoses and self-reported health status in veterans with epilepsy. ANCOVA models were used to derive adjusted SF-36V scores for individuals with epilepsy alone (N = 7379) or with additional psychiatric conditions (N = 6320): depression, schizophrenia, bipolar disorder, anxiety disorder, substance abuse, and posttraumatic stress disorder (PTSD). Compared with patients with epilepsy alone, scores of veterans with comorbid psychiatric diagnoses averaged 21% lower across all domains. Role Limitation scales exhibited the greatest decrement across domains. A PTSD diagnosis consistently corresponded to lower scores, followed by depression. Schizophrenia contributed the least detriment to perceived health status. Comorbid psychiatric conditions impart significant emotional and physical burdens, requiring timely recognition and treatment of these disorders. Patients with epilepsy are uniquely at risk for high physical-psychiatric comorbidity profiles, with concomitant losses in perceived health status.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalEpilepsy and Behavior
Volume10
Issue number4
DOIs
StatePublished - Jun 2007

Fingerprint

Health Status
Psychiatry
Epilepsy
Veterans
Post-Traumatic Stress Disorders
Mental Disorders
Schizophrenia
Depression
Anxiety Disorders
Bipolar Disorder
Substance-Related Disorders
Comorbidity
Mental Health
Therapeutics

Keywords

  • Comorbid psychiatric conditions
  • Epilepsy
  • Health status
  • Veterans

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Zeber, J. E., Copeland, L. A., Amuan, M., Cramer, J. A., & Pugh, M. J. V. (2007). The role of comorbid psychiatric conditions in health status in epilepsy. Epilepsy and Behavior, 10(4), 539-546. https://doi.org/10.1016/j.yebeh.2007.02.008

The role of comorbid psychiatric conditions in health status in epilepsy. / Zeber, John E.; Copeland, Laurel A.; Amuan, Megan; Cramer, Joyce A.; Pugh, Mary Jo V.

In: Epilepsy and Behavior, Vol. 10, No. 4, 06.2007, p. 539-546.

Research output: Contribution to journalArticle

Zeber, JE, Copeland, LA, Amuan, M, Cramer, JA & Pugh, MJV 2007, 'The role of comorbid psychiatric conditions in health status in epilepsy', Epilepsy and Behavior, vol. 10, no. 4, pp. 539-546. https://doi.org/10.1016/j.yebeh.2007.02.008
Zeber, John E. ; Copeland, Laurel A. ; Amuan, Megan ; Cramer, Joyce A. ; Pugh, Mary Jo V. / The role of comorbid psychiatric conditions in health status in epilepsy. In: Epilepsy and Behavior. 2007 ; Vol. 10, No. 4. pp. 539-546.
@article{0a36bb71c1dc4fc3bf33488425a2eaf8,
title = "The role of comorbid psychiatric conditions in health status in epilepsy",
abstract = "Comorbid psychiatric conditions are highly prevalent in patients with epilepsy, yet the long-term implications across multiple mental health conditions are poorly understood. We examined the association between psychiatric diagnoses and self-reported health status in veterans with epilepsy. ANCOVA models were used to derive adjusted SF-36V scores for individuals with epilepsy alone (N = 7379) or with additional psychiatric conditions (N = 6320): depression, schizophrenia, bipolar disorder, anxiety disorder, substance abuse, and posttraumatic stress disorder (PTSD). Compared with patients with epilepsy alone, scores of veterans with comorbid psychiatric diagnoses averaged 21{\%} lower across all domains. Role Limitation scales exhibited the greatest decrement across domains. A PTSD diagnosis consistently corresponded to lower scores, followed by depression. Schizophrenia contributed the least detriment to perceived health status. Comorbid psychiatric conditions impart significant emotional and physical burdens, requiring timely recognition and treatment of these disorders. Patients with epilepsy are uniquely at risk for high physical-psychiatric comorbidity profiles, with concomitant losses in perceived health status.",
keywords = "Comorbid psychiatric conditions, Epilepsy, Health status, Veterans",
author = "Zeber, {John E.} and Copeland, {Laurel A.} and Megan Amuan and Cramer, {Joyce A.} and Pugh, {Mary Jo V}",
year = "2007",
month = "6",
doi = "10.1016/j.yebeh.2007.02.008",
language = "English (US)",
volume = "10",
pages = "539--546",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - The role of comorbid psychiatric conditions in health status in epilepsy

AU - Zeber, John E.

AU - Copeland, Laurel A.

AU - Amuan, Megan

AU - Cramer, Joyce A.

AU - Pugh, Mary Jo V

PY - 2007/6

Y1 - 2007/6

N2 - Comorbid psychiatric conditions are highly prevalent in patients with epilepsy, yet the long-term implications across multiple mental health conditions are poorly understood. We examined the association between psychiatric diagnoses and self-reported health status in veterans with epilepsy. ANCOVA models were used to derive adjusted SF-36V scores for individuals with epilepsy alone (N = 7379) or with additional psychiatric conditions (N = 6320): depression, schizophrenia, bipolar disorder, anxiety disorder, substance abuse, and posttraumatic stress disorder (PTSD). Compared with patients with epilepsy alone, scores of veterans with comorbid psychiatric diagnoses averaged 21% lower across all domains. Role Limitation scales exhibited the greatest decrement across domains. A PTSD diagnosis consistently corresponded to lower scores, followed by depression. Schizophrenia contributed the least detriment to perceived health status. Comorbid psychiatric conditions impart significant emotional and physical burdens, requiring timely recognition and treatment of these disorders. Patients with epilepsy are uniquely at risk for high physical-psychiatric comorbidity profiles, with concomitant losses in perceived health status.

AB - Comorbid psychiatric conditions are highly prevalent in patients with epilepsy, yet the long-term implications across multiple mental health conditions are poorly understood. We examined the association between psychiatric diagnoses and self-reported health status in veterans with epilepsy. ANCOVA models were used to derive adjusted SF-36V scores for individuals with epilepsy alone (N = 7379) or with additional psychiatric conditions (N = 6320): depression, schizophrenia, bipolar disorder, anxiety disorder, substance abuse, and posttraumatic stress disorder (PTSD). Compared with patients with epilepsy alone, scores of veterans with comorbid psychiatric diagnoses averaged 21% lower across all domains. Role Limitation scales exhibited the greatest decrement across domains. A PTSD diagnosis consistently corresponded to lower scores, followed by depression. Schizophrenia contributed the least detriment to perceived health status. Comorbid psychiatric conditions impart significant emotional and physical burdens, requiring timely recognition and treatment of these disorders. Patients with epilepsy are uniquely at risk for high physical-psychiatric comorbidity profiles, with concomitant losses in perceived health status.

KW - Comorbid psychiatric conditions

KW - Epilepsy

KW - Health status

KW - Veterans

UR - http://www.scopus.com/inward/record.url?scp=34248649356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248649356&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2007.02.008

DO - 10.1016/j.yebeh.2007.02.008

M3 - Article

VL - 10

SP - 539

EP - 546

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 4

ER -