Abstract
Purpose: To systematically review the value of serum inflammatory markers to diagnose diabetic foot osteomyelitis (DFO). Study selection: Studies to diagnose DFO using biomarkers erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-2, IL-6, IL-8) and tumor necrosis factor alfa (TNFα) were retrieved from EMBASE and PubMed with no language restrictions through July 2014. Data extraction: We summarized clinical characteristics of the studies and used bivariate random effects models and summary receiver operating characteristic curves to estimate sensitivity and specificity for each marker. Data synthesis: A total of 8 qualifying studies were included in our meta-analysis. Bivariate pooled sensitivity and specificity of the 6 studies examining ESR were 0.81 (95% CI 0.71-0.88) and 0.90 (95% CI 0.75-0.96) respectively. Due to the paucity of data, models did not converge for the other biomarkers. Conclusions: From the inflammatory markers, ESR appears to be the best laboratory test to identify patients with DFO.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 396-402 |
| Number of pages | 7 |
| Journal | Current diabetes reviews |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2016 |
| Externally published | Yes |
Keywords
- Biomarkers
- C-reactive protein
- Diabetic foot
- Diabetic foot infection
- Diagnosis
- Erythrocyte sedimentation rate
- Osteomyelitis
- Procalcitonin
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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