The role of apoptosis in the development and function of T lymphocytes

Nu Zhang, Heather Hartig, Ivan Dzhagalov, David Draper, You Wen He

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.

Original languageEnglish (US)
Pages (from-to)749-769
Number of pages21
JournalCell Research
Volume15
Issue number10
DOIs
StatePublished - Nov 28 2005
Externally publishedYes

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Keywords

  • Apoptosis
  • Effector
  • Memory T lymphocytes
  • Thymocyte

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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