The role of anti-infectives in the treatment of refractory asthma

Diego Jose Maselli, Sandra Adams, Jay Peters

Research output: Contribution to journalReview articlepeer-review

Abstract

Refractory asthma not only has a significant effect on quality of life, but also imposes an economic burden on society. Increasing evidence suggests that there is a pathophysiologic interaction between infection and allergic disease in patients with severe or refractory asthma. Therapeutic trials of macrolides and azoles are being utilized in some patients with refractory asthma who fail to respond to standard therapy. In this article we review the definition of refractory asthma and the potential pathophysiologic interactions between infection and allergic disease. Emerging data suggest that microorganisms and their byproducts may be a therapeutic target in the therapy of patients with severe or refractory asthma.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalTherapeutic Advances in Respiratory Disease
Volume5
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • antibiotics in asthma
  • atypical bacteria
  • refractory asthma
  • viral infections

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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