The Role of Aldosteronism in Causing Obesity-Related Cardiovascular Risk

David A. Calhoun, Kumar Sharma

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


A large body of evidence strongly links aldosterone to development and progression of cardiovascular disease, including vascular stiffness, left ventricular hypertrophy, congestive heart failure, chronic kidney disease, and, especially, hypertension. Emerging data suggest that adipocytes may serve as a source of aldosterone, either directly or indirectly, through the release of aldosterone-stimulating factors. If adipocytes are confirmed to have an important contribution to hyperaldosteronism, it would have significant clinical implications in linking aldosterone to obesity-related increases in cardiovascular risk. Such a cause-and-effect situation would then provide the opportunity to reverse that risk with preferential use of aldosterone antagonists in obese patients.

Original languageEnglish (US)
Pages (from-to)517-527
Number of pages11
JournalCardiology Clinics
Issue number3
StatePublished - Aug 2010
Externally publishedYes


  • Adipocyte
  • Aldosterone
  • Eplerenone
  • Hypertension
  • Obesity
  • Spironolactone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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