The role of γδ T-cells in the healing of burn wounds

Richard F. Oppeltz, Martin G. Schwacha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Major burn induces a pathophysiological response that has a marked inflammatory component contributing to the development of a systemic inflammatory response (SIRS) and a wide range of complications that include, immunosuppression, sepsis, delayed wound healing and multiple organ failure. While improvements in burn patient care have been made, the vast majority of problems which still develop for burn patients are associated with the healing process. Proper healing the burn wound site is a critical component of the patient's successful recovery from burn injury. The process of burn wound healing is complex involving a series of overlapping phases. In this regard, a unique T-cell population expressing the γδ T-cell receptor (γδ T-cells) has been shown to regulate inflammation and play an important role in wound repair. While γδ T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's healing response to burn. This review will focus on the role of γδ T-cells in inflammatory response to injury and their potential as therapeutic targets for improving healing responses and reducing burn patient morbidity and mortality.

Original languageEnglish (US)
Title of host publicationWound Healing
Subtitle of host publicationProcess, Phases and Promoting
PublisherNova Science Publishers, Inc.
Pages95-108
Number of pages14
ISBN (Print)9781612098470
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The role of γδ T-cells in the healing of burn wounds'. Together they form a unique fingerprint.

Cite this