The RNA polymerase 2 C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome

Dong Hyuk Heo, Inhea Yoo, Jiwon Kong, Michael Lidschreiber, Andreas Mayer, Byung Yi Choi, Yoonsoo Hahn, Patrick Cramer, Stephen Buratowski, Minkyu Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Distinct termination pathways for yeast RNA polymerase II (RNApII) employ proteins (Nrd1 and Rtt103) recognizing different phospho-forms of the RNApII C-terminal domain (CTD). Results: Alteration of CTD-binding specificity of Nrd1 significantly affects RNApII termination. Conclusion: Differential interaction between RNApII CTD and termination factors is crucial in choosing a termination pathway. Significance: CTD-interacting domain of Nrd1 couples termination and RNA processing by the nuclear exosome.

Original languageEnglish (US)
Pages (from-to)36676-36690
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number51
DOIs
StatePublished - Dec 20 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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