TY - JOUR
T1 - The RNA-binding protein musashi1
T2 - A major player in intestinal epithelium renewal and colon cancer development
AU - Plateroti, Michelina
AU - De Araujo, Patricia Rosa
AU - Da Silva, Acarizia Eduardo
AU - Penalva, Luiz O.F.
N1 - Funding Information:
Acknowledgments The authors thank Suzanne Burns for critically reading the manuscript. Work in the Penalva laboratory is supported by the Voelcker Fund and NIH (R01 HG006015). The work in the Plater-oti laboratory is supported by the Institut National pour le Cancer and the Ligue Contre le Cancer Department du Rhone.
PY - 2012/12
Y1 - 2012/12
N2 - Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identified in the human genome and several of them have been shown to control gene networks associated with relevant cancer processes. A more systematic characterization of RBPs starts to reveal that similar to transcription factors, they can function as tumor suppressors or oncogenes. A relevant example is Musashi1 (Msi1), which is emerging as a critical regulator of tumorigenesis in multiple cancer types, including colon cancer. Msi1 is a stem marker in several tissues and is critical in maintaining the balance between self-renewal and differentiation. However, a boost in Msi1 expression can most likely lead cells towards an oncogenic pathway. In this article, we discuss the parallels between Msi1 function in normal renewal of intestinal epithelium and in colon cancer.
AB - Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identified in the human genome and several of them have been shown to control gene networks associated with relevant cancer processes. A more systematic characterization of RBPs starts to reveal that similar to transcription factors, they can function as tumor suppressors or oncogenes. A relevant example is Musashi1 (Msi1), which is emerging as a critical regulator of tumorigenesis in multiple cancer types, including colon cancer. Msi1 is a stem marker in several tissues and is critical in maintaining the balance between self-renewal and differentiation. However, a boost in Msi1 expression can most likely lead cells towards an oncogenic pathway. In this article, we discuss the parallels between Msi1 function in normal renewal of intestinal epithelium and in colon cancer.
KW - Colon cancer
KW - Musashi1
KW - RNA-binding proteins
KW - Translation regulation
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U2 - 10.1007/s11888-012-0141-6
DO - 10.1007/s11888-012-0141-6
M3 - Article
C2 - 23914149
AN - SCOPUS:84869127674
SN - 1556-3790
VL - 8
SP - 290
EP - 297
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
IS - 4
ER -