The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity

Sarah Genon, Hai Li, Lingzhong Fan, Veronika I. Müller, Edna C. Cieslik, Felix Hoffstaedter, Andrew T. Reid, Robert Langner, Christian Grefkes, Peter T. Fox, Susanne Moebus, Svenja Caspers, Katrin Amunts, Tianzi Jiang, Simon B. Eickhoff

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.

Original languageEnglish (US)
Pages (from-to)2095-2110
Number of pages16
JournalCerebral cortex (New York, N.Y. : 1991)
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2017

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Parietal Lobe
Diffusion Tensor Imaging
Motor Cortex
Eye Movements
Prefrontal Cortex
Short-Term Memory
Cognition
Hand

Keywords

  • activation likelihood estimation
  • clustering
  • functional connectivity
  • parcellation
  • premotor cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Genon, S., Li, H., Fan, L., Müller, V. I., Cieslik, E. C., Hoffstaedter, F., ... Eickhoff, S. B. (2017). The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity. Cerebral cortex (New York, N.Y. : 1991), 27(3), 2095-2110. https://doi.org/10.1093/cercor/bhw065

The Right Dorsal Premotor Mosaic : Organization, Functions, and Connectivity. / Genon, Sarah; Li, Hai; Fan, Lingzhong; Müller, Veronika I.; Cieslik, Edna C.; Hoffstaedter, Felix; Reid, Andrew T.; Langner, Robert; Grefkes, Christian; Fox, Peter T.; Moebus, Susanne; Caspers, Svenja; Amunts, Katrin; Jiang, Tianzi; Eickhoff, Simon B.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 27, No. 3, 01.03.2017, p. 2095-2110.

Research output: Contribution to journalArticle

Genon, S, Li, H, Fan, L, Müller, VI, Cieslik, EC, Hoffstaedter, F, Reid, AT, Langner, R, Grefkes, C, Fox, PT, Moebus, S, Caspers, S, Amunts, K, Jiang, T & Eickhoff, SB 2017, 'The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity', Cerebral cortex (New York, N.Y. : 1991), vol. 27, no. 3, pp. 2095-2110. https://doi.org/10.1093/cercor/bhw065
Genon, Sarah ; Li, Hai ; Fan, Lingzhong ; Müller, Veronika I. ; Cieslik, Edna C. ; Hoffstaedter, Felix ; Reid, Andrew T. ; Langner, Robert ; Grefkes, Christian ; Fox, Peter T. ; Moebus, Susanne ; Caspers, Svenja ; Amunts, Katrin ; Jiang, Tianzi ; Eickhoff, Simon B. / The Right Dorsal Premotor Mosaic : Organization, Functions, and Connectivity. In: Cerebral cortex (New York, N.Y. : 1991). 2017 ; Vol. 27, No. 3. pp. 2095-2110.
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