The right dorsal premotor mosaic: Organization, functions, and connectivity

Sarah Genon; Hai Li; Lingzhong Fan; Veronika I. Müller; Edna C. Cieslik; Felix Hoffstaedter; Andrew T. Reid; Robert Langner; Christian Grefkes; Peter T. Fox; Susanne Moebus; Svenja Caspers; Katrin Amunts; Tianzi Jiang; Simon B. Eickhoff

doi:10.1093/cercor/bhw065

The right dorsal premotor mosaic: Organization, functions, and connectivity

Sarah Genon, Hai Li, Lingzhong Fan, Veronika I. Müller, Edna C. Cieslik, Felix Hoffstaedter, Andrew T. Reid, Robert Langner, Christian Grefkes, Peter T. Fox, Susanne Moebus, Svenja Caspers, Katrin Amunts, Tianzi Jiang, Simon B. Eickhoff

Department of Radiology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions.We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using metaanalytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally,we found 4) a dorsal subregion, preferentially related to handmovements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.

Original language	English (US)
Pages (from-to)	2095-2110
Number of pages	16
Journal	Cerebral Cortex
Volume	27
Issue number	3
DOIs	https://doi.org/10.1093/cercor/bhw065
State	Published - Mar 1 2017

Keywords

Activation likelihood estimation
Clustering
Functional connectivity
Parcellation
Premotor cortex

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1093/cercor/bhw065

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title = "The right dorsal premotor mosaic: Organization, functions, and connectivity",

abstract = "The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions.We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using metaanalytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally,we found 4) a dorsal subregion, preferentially related to handmovements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.",

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AU - Genon, Sarah

AU - Li, Hai

AU - Fan, Lingzhong

AU - Müller, Veronika I.

AU - Cieslik, Edna C.

AU - Hoffstaedter, Felix

AU - Reid, Andrew T.

AU - Langner, Robert

AU - Grefkes, Christian

AU - Fox, Peter T.

AU - Moebus, Susanne

AU - Caspers, Svenja

AU - Amunts, Katrin

AU - Jiang, Tianzi

AU - Eickhoff, Simon B.

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AB - The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions.We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using metaanalytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally,we found 4) a dorsal subregion, preferentially related to handmovements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.

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KW - Functional connectivity

KW - Parcellation

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The right dorsal premotor mosaic: Organization, functions, and connectivity

Abstract

Keywords

ASJC Scopus subject areas

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