The removal of the carboxy-terminal region of tubulin favors its vinblastine-induced aggregation into spiral-like structures

Luis Serrano, Javier De La Torre, Richard F. Luduena, Jesus Avila

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Vinblastine induces brain tubulin to assemble into spirals. This process is stimulated by microtubule-associated proteins (MAPs) which copolymerize with brain microtubules assembled in vitro. When the carboxy terminal of tubulin is removed by subtilisin digestion, vinblastine readily induces the aggregation of tubulin into spiral-like or circular structures, even in the absence of MAPs. These results suggest that in the absence of MAPs, the carboxy-terminal domain of tubulin may inhibit vinblastine-induced polymerization of tubulin into spiral-like structures.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalArchives of Biochemistry and Biophysics
Volume249
Issue number2
DOIs
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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