The relentless effects of the aging process on protein turnover

Walter F. Ward

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Protein turnover encompasses the processes of protein synthesis and protein degradation. Because of the essential structural and catalytic roles that proteins play in the cell, there has been a long-standing interest in the effects of aging on protein turnover. The purpose of this review is to incorporate relevant data published since the area was previously reviewed and to provide an update on the status of research with particular attention to the pathways of protein degradation.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
Issue number3
StatePublished - Jan 1 2000


  • Aging
  • Lysosome
  • Proteasome
  • Protein degradation
  • Protein synthesis
  • Protein turnover

ASJC Scopus subject areas

  • Aging
  • Gerontology
  • Geriatrics and Gerontology


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