The relative potency of pentobarbital in suppressing the kainic acid- or the N-methyl-D-aspartic acid-induced enhancement of cGMP in cerebellar cells

William W. Morgan, Jairo Bermudez, Xiaoying Chang

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Primary cultures of rat cerebellar cells were pretrcated with various dosages of pentobarbital before the addition of kainic acid or N-methyl-D-aspartic acid in order to assess effects of this drug on the enhancement of cyclic guanosine-3',5'-phosphate (cyclic GMP) mediated by these excitatory agonists. Pentobarbital significantly suppressed kainic acid-induced increases in this cyclic nucleotide at concentrations as low as 5 μM but was only effective in suppressing the N-methyl-D-aspartic acid enhancement at dosages of 100 μM or greater. These data suggest that this barbiturate is a more effective depressant of the stimulatory effects of kainic acid as compared to N-mcthyl-D-aspartic acid.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalEuropean Journal of Pharmacology
Volume204
Issue number3
DOIs
StatePublished - Nov 12 1991

Keywords

  • Barbiturates
  • cGMP
  • Dicarboxylic amino acids
  • Kainic acid
  • NMDA (N-methyl-D-aspartic acid)
  • Quisqualic acid

ASJC Scopus subject areas

  • Pharmacology

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