The relationship of personality traits to substance abuse in patients with bipolar disorder

Gonzalo Haro, Joseph R. Calabrese, Christina Larsson, Edwin R. Shirley, Eva Martín, Carmen Leal, Pedro L. Delgado

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose: The aim of this study is to determine if personality traits contribute to the likelihood of substance abuse in Bipolar Disorder (BD). Subjects/materials and methods: Fifty-nine patients meeting DSM-IV criteria for BD: 20 without any history of Substance Related Disorder (SRD), 21 with a lifetime history of SRD but without current SRD, and 18 with current SRD. Patients filled out the TCI, the differences were analyzed by ANOVA and the likelihood was obtained by Multinomial Logistic Regression. Results: Only Novelty Seeking (NS) is statistically different between the groups. Patients with BD with current SRD have higher rates in NS than those with past SRD, and those without a history of SRD. NS was confirmed as a predicting variable, both to current SRD (OR [CI 95%] = 1.039/1.351; p = 0.011) and past SRD (OR [CI 95%] = 1.004/1.277; p = 0.042) on patients with BD. Discussion: The results shown would appear to confirm the relationship of NS with the SRD, so long as there is no clear evidence that indicates the association of NS with BD. Conclusions: There appears a greater predisposition to develop SRD in those patients with a higher degree of NS. The use of the Cloninger's TCI could be used in BD to determine the risk of developing an SRD. Early detection might help improve prognosis.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalEuropean Psychiatry
Issue number5
StatePublished - Jul 2007


  • Bipolar disorder
  • Cloninger's TCI
  • Novelty seeking
  • Personality
  • Substance related disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health


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