Abstract
The authors evaluated the relationship of methadone dose to retention in treatment and to urine tests for morphine and cocaine in a cohort of 610 opioid users admitted to methadone maintenance and followed for 1 year. Methadone dosing was flexible, with patient participation in dose decisions. The maximum dose during treatment ranged from 10 mg to 110 mg, with a mean of 52 mg. Higher doses were associated with increased retention through the dose range of 60 mg-69 mg. Dose was not related to the likelihood of a positive morphine test but was related to the likelihood of a positive cocaine test. In this study, with flexible dosing and patient participation in dose decisions, patients were retained on methadone about as well as was reported in a previous study with patients on a fixed dose of 80 mg.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 246-255 |
| Number of pages | 10 |
| Journal | American Journal on Addictions |
| Volume | 6 |
| Issue number | 3 |
| State | Published - Jun 1997 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
The relationship of methadone dose and other variables to outcomes of methadone maintenance. / Maddux, James F.; Prihoda, Thomas J.; Vogtsberger, Kenneth N.
In: American Journal on Addictions, Vol. 6, No. 3, 06.1997, p. 246-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship of methadone dose and other variables to outcomes of methadone maintenance
AU - Maddux, James F.
AU - Prihoda, Thomas J.
AU - Vogtsberger, Kenneth N.
PY - 1997/6
Y1 - 1997/6
N2 - The authors evaluated the relationship of methadone dose to retention in treatment and to urine tests for morphine and cocaine in a cohort of 610 opioid users admitted to methadone maintenance and followed for 1 year. Methadone dosing was flexible, with patient participation in dose decisions. The maximum dose during treatment ranged from 10 mg to 110 mg, with a mean of 52 mg. Higher doses were associated with increased retention through the dose range of 60 mg-69 mg. Dose was not related to the likelihood of a positive morphine test but was related to the likelihood of a positive cocaine test. In this study, with flexible dosing and patient participation in dose decisions, patients were retained on methadone about as well as was reported in a previous study with patients on a fixed dose of 80 mg.
AB - The authors evaluated the relationship of methadone dose to retention in treatment and to urine tests for morphine and cocaine in a cohort of 610 opioid users admitted to methadone maintenance and followed for 1 year. Methadone dosing was flexible, with patient participation in dose decisions. The maximum dose during treatment ranged from 10 mg to 110 mg, with a mean of 52 mg. Higher doses were associated with increased retention through the dose range of 60 mg-69 mg. Dose was not related to the likelihood of a positive morphine test but was related to the likelihood of a positive cocaine test. In this study, with flexible dosing and patient participation in dose decisions, patients were retained on methadone about as well as was reported in a previous study with patients on a fixed dose of 80 mg.
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M3 - Article
C2 - 9256991
AN - SCOPUS:0030788595
VL - 6
SP - 246
EP - 255
JO - American Journal on Addictions
JF - American Journal on Addictions
SN - 1055-0496
IS - 3
ER -