The relationship of methadone dose and other variables to outcomes of methadone maintenance

James F. Maddux, Thomas J. Prihoda, Kenneth N. Vogtsberger

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The authors evaluated the relationship of methadone dose to retention in treatment and to urine tests for morphine and cocaine in a cohort of 610 opioid users admitted to methadone maintenance and followed for 1 year. Methadone dosing was flexible, with patient participation in dose decisions. The maximum dose during treatment ranged from 10 mg to 110 mg, with a mean of 52 mg. Higher doses were associated with increased retention through the dose range of 60 mg-69 mg. Dose was not related to the likelihood of a positive morphine test but was related to the likelihood of a positive cocaine test. In this study, with flexible dosing and patient participation in dose decisions, patients were retained on methadone about as well as was reported in a previous study with patients on a fixed dose of 80 mg.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalAmerican Journal on Addictions
Volume6
Issue number3
StatePublished - Jun 1 1997

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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