The Relationship between Plasma Oxytocin and Executive Functioning in Huntington's Disease: A Pilot Study

Emily R. Fisher; Natalia P. Rocha; Diego A. Morales-Scheihing; Venugopal Reddy Venna; Erin E. Furr-Stimming; Antonio L. Teixeira; Maria A. Rossetti

doi:10.3233/JHD-210467

The Relationship between Plasma Oxytocin and Executive Functioning in Huntington's Disease: A Pilot Study

Emily R. Fisher, Natalia P. Rocha, Diego A. Morales-Scheihing, Venugopal Reddy Venna, Erin E. Furr-Stimming, Antonio L. Teixeira, Maria A. Rossetti

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The role of oxytocin (OT) in social cognition of patients with Huntington's disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.

Original language	English (US)
Pages (from-to)	349-354
Number of pages	6
Journal	Journal of Huntington's disease
Volume	10
Issue number	3
DOIs	https://doi.org/10.3233/JHD-210467
State	Published - 2021
Externally published	Yes

Keywords

cognition
depression
Huntington's disease
oxytocin

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience

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10.3233/JHD-210467

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title = "The Relationship between Plasma Oxytocin and Executive Functioning in Huntington's Disease: A Pilot Study",

abstract = "The role of oxytocin (OT) in social cognition of patients with Huntington's disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.",

keywords = "cognition, depression, Huntington's disease, oxytocin",

author = "Fisher, {Emily R.} and Rocha, {Natalia P.} and Morales-Scheihing, {Diego A.} and Venna, {Venugopal Reddy} and Furr-Stimming, {Erin E.} and Teixeira, {Antonio L.} and Rossetti, {Maria A.}",

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AU - Fisher, Emily R.

AU - Rocha, Natalia P.

AU - Morales-Scheihing, Diego A.

AU - Venna, Venugopal Reddy

AU - Furr-Stimming, Erin E.

AU - Teixeira, Antonio L.

AU - Rossetti, Maria A.

PY - 2021

Y1 - 2021

N2 - The role of oxytocin (OT) in social cognition of patients with Huntington's disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.

AB - The role of oxytocin (OT) in social cognition of patients with Huntington's disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.

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KW - depression

KW - Huntington's disease

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The Relationship between Plasma Oxytocin and Executive Functioning in Huntington's Disease: A Pilot Study

Abstract

Keywords

ASJC Scopus subject areas

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