The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects

Katherine H. Karlsgodt, David C. Glahn, Theo G.M. van Erp, Sebastian Therman, Matti Huttunen, Marko Manninen, Jaakko Kaprio, Mark S. Cohen, Jouko Lönnqvist, Tyrone D. Cannon

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

While behavioral research shows working memory impairments in schizophrenics and their relatives, functional neuroimaging studies of patients and healthy controls show conflicting findings of hypo- and hyperactivation, possibly indicating different relationships between physiological activity and performance. In a between-subjects regression analysis of fMRI activation and performance, low performance was associated with relatively lower activation in patients than controls, while higher performance was associated with higher activation in patients than controls in DLPFC and parietal cortex, but not occipital cortex, with unaffected twins of schizophrenics being intermediate between the groups. Accordingly, this supports the idea that both hyper and hypoactivation may be possible along a continuum of behavioral performance in a way consistent with a neural inefficiency model. Further, this study offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalSchizophrenia research
Volume89
Issue number1-3
DOIs
StatePublished - Jan 2007
Externally publishedYes

Keywords

  • Genetic
  • Inefficiency
  • Schizophrenia
  • Twin
  • Working memory
  • fMRI

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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